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Low risk of anti-human leukocyte antigen antibody sensitization after combined kidney and islet transplantation

Marangon, Nicola
Demuylder-Mischler, Sandrine
Pongratz, Gilles
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Published in Transplantation. 2008, vol. 86, no. 2, p. 357-9
Abstract Anti-human leukocyte antigen (HLA) antibody could lead to humoral rejection and a decrease in graft survival after kidney transplantation. A recent report has suggested that islet transplantation alone is associated with a high rate of sensitization. The withdrawal of the immunosuppressive therapy because of the progressive nonfunction of the islets could explain the high rate of sensitization. Because the specific risk of immunization of multiple islet infusions remains unknown, we studied the immunization rate in our cohort of multiple islet infusions transplant recipients. De novo anti-HLA antibodies were analyzed in 37 patients after islets alone (n=8), islet-after-kidney (n=13), and simultaneous islet-kidney (n=16) transplantation by solid phase assays over time. The rate of immunization was 10.8% that is comparable with the risk of immunization after kidney transplantation alone. Multiple islet infusions do not represent a specific risk for the development of anti-HLA antibodies after combined kidney-islets transplantation.
Keywords AdultCohort StudiesFemaleGraft RejectionHLA Antigens/chemistry/immunologyHistocompatibility TestingHumansImmunosuppressive Agents/therapeutic useIslets of Langerhans/pathologyIslets of Langerhans Transplantation/instrumentation/methodsKidney Transplantation/immunology/methodsMaleMiddle AgedRisk FactorsTime Factors
PMID: 18645502
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Research groups Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
La transplantation d'îlots de Langerhans (623)
Transplantation Immunologie et Osteoimmunologie (561)
(ISO format)
FERRARI-LACRAZ, Sylvie et al. Low risk of anti-human leukocyte antigen antibody sensitization after combined kidney and islet transplantation. In: Transplantation, 2008, vol. 86, n° 2, p. 357-9. doi: 10.1097/TP.0b013e31817ba628 https://archive-ouverte.unige.ch/unige:1217

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Deposited on : 2009-03-23

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