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Scientific article
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English

Strand separation in negatively supercoiled dna

ContributorsMazza, Christian
Published inJournal of mathematical biology, vol. 51, no. 2, p. 198-216
Publication date2005
Abstract

We consider Benham's model for strand separation in negatively supercoiled circular DNA, and study denaturation as function of the superhelical density k < 0. We propose a statistical version of this model, based on bayesian segmentation methods of current use in bioinformatics; this leads to new algorithms with priors adapted to supercoiled DNA, taking into account the random nature of the free energies needed to denature hydrogen bonds.

Classification
  • arxiv : cond-mat.stat-mech
Note20 pages
Citation (ISO format)
MAZZA, Christian. Strand separation in negatively supercoiled dna. In: Journal of mathematical biology, 2005, vol. 51, n° 2, p. 198–216. doi: 10.1007/s00285-005-0320-z
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ISSN of the journal0303-6812
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