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Cellular Uptake Mediated by Cyclic Oligochalcogenides

Published in Chimia. 2019, vol. 73, no. 4, p. 304-307
Abstract Cellular uptake is one of the central challenges in chemical biology and beyond. With the objective to find conceptually innovative ways to enter into cells, cyclic oligochalcogenides (COCs) are emerging as powerful tools. Increasing ring tension is shown to maximize speed and selectivity of dynamic covalent exchange chemistry on the way into cells. However, simple dynamic covalent attachment immobilizes the transporters on membrane proteins, resulting in endosomal capture. To move across the membrane into the cytosol, dynamic covalent COC opening has to produce high acidity chalcogenols that remain deprotonated in neutral water and, according to the present working hypothesis, initiate COC walking along disulfide tracks in membrane proteins, across the bilayer and into the cytosol. Compatibility of diselenolanes, the current 'lord of the rings', with the delivery of larger substrates of biological relevance is currently under investigation.
Keywords Cellular uptakeDynamic covalent chemistryMolecular walkersReactive intermediates
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Research group Groupe Matile
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MARTINENT, Rémi et al. Cellular Uptake Mediated by Cyclic Oligochalcogenides. In: Chimia, 2019, vol. 73, n° 4, p. 304-307. doi: 10.2533/chimia.2019.304 https://archive-ouverte.unige.ch/unige:120454

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Deposited on : 2019-07-08

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