Four porphyry Cu-Mo systems were investigated by Re-Os molybdenite geochronology to constrain their timing with respect to the geodynamic and magmatic evolution of the Eastern Pontides, Turkey. Molybdenite from the Ispir-Ulutaş deposit yielded a Re-Os age of 131.0±0.7 Ma, which is consistent with Early Cretaceous U-Pb LA-ICP-MS zircon ages of local calc-alkaline intrusions. It demonstrates that porphyry deposits were already formed during Early Cretaceous subduction of the Neotethys along the Eastern Pontides, and that they can be correlated with porphyry Cu events in the adjacent Lesser Caucasus. Molybdenite Re-Os ages of 76.0±0.4 and 75.7±0.4 Ma at the Elbeyli prospect and 77.2±1.0 Ma at the Emeksen prospect overlap with U-Pb LA-ICP-MS zircon ages of shoshonitic to high-K calc-alkaline intrusions in the region, which were emplaced during Late Cretaceous Neotethys subduction. A 50.7±0.3 Ma molybdenite Re-Os age at the Güzelyayla deposit confirms porphyry Cu-Mo emplacement coeval with Eocene post-collisional, calc-alkaline adakitic magmatism of the Eastern Pontides. An electron microprobe study of molybdenite samples, supplemented by data obtained during Re-Os dating, shows that the Eocene Güzelyayla deposit and the Late Cretaceous Emeksen prospect have the highest Re-enrichment. Post-collisional melting of a thickened mafic lower continental crust and melting of a metasomatized lithospheric mantle with little to no interaction with upper crustal rocks may explain the Re enrichment at Güzelyayla and Emeksen, respectively.