UNIGE document Scientific Article
previous document  unige:119640  next document
add to browser collection
Title

Abnormal development of early auditory processing in 22q11.2 deletion syndrome

Authors
Published in Translational Psychiatry. 2019, vol. 9, no. 1, 138
Abstract The 22q11.2 Deletion Syndrome (22q11.2 DS) is one of the highest genetic risk factors for the development of schizophrenia spectrum disorders. In schizophrenia, reduced amplitude of the frequency mismatch negativity (fMMN) has been proposed as a promising neurophysiological marker for progressive brain pathology. In this longitudinal study in 22q11.2 DS, we investigate the progression of fMMN between childhood and adolescence, a vulnerable period for brain maturation. We measured evoked potentials to auditory oddball stimuli in the same sample of 16 patients with 22q11.2 DS and 14 age-matched controls in childhood and adolescence. In addition, we cross-sectionally compared an increased sample of 51 participants with 22q11.2 DS and 50 controls divided into two groups (8-14 and 14-20 years). The reported results are obtained using the fMMN difference waveforms. In the longitudinal design, the 22q11.2 deletion carriers exhibit a significant reduction in amplitude and a change in topographic patterns of the mismatch negativity response from childhood to adolescence. The same effect, reduced mismatch amplitude in adolescence, while preserved during childhood, is observed in the cross-sectional study. These results point towards functional changes within the brain network responsible for the fMMN. In addition, the adolescents with 22q11.2 DS displayed a significant increase in amplitude over central electrodes during the auditory N1 component. No such differences, reduced mismatch response nor increased N1, were observed in the typically developing group. These findings suggest different developmental trajectories of early auditory sensory processing in 22q11.2 DS and functional changes that emerge during the critical period of increased risk for schizophrenia spectrum disorders.
Identifiers
PMID: 30992427
Full text
Article (Published version) (901 Kb) - public document Free access
Structures
Research groups Laboratoire d'imagerie et de psychopathologie développementale (693)
Organisation et plasticité des réseaux neuronaux cérébraux (148)
Projects
FNS: NCCR 51NF40–158776
FNS: 320030_159705; 324730_144260
Citation
(ISO format)
CANTONAS, Lucia-Manuela et al. Abnormal development of early auditory processing in 22q11.2 deletion syndrome. In: Translational Psychiatry, 2019, vol. 9, n° 1, p. 138. doi: 10.1038/s41398-019-0473-y https://archive-ouverte.unige.ch/unige:119640

300 hits

109 downloads

Update

Deposited on : 2019-06-18

Export document
Format :
Citation style :