Here, we present a first description of skin reflectivity in thirteen corn snake morphs, and combine it with Transmission Electron Microscopy (TEM) imaging, to characterize the chromatophore distribution in the dermis/epidermis. Our results suggest that, as it is the case in many fish and amphibians, as well as other reptilian species, xanthophores, melanocytes and iridophores are the three chromatophore types responsible of the corn snake skin coloration. We describe the modulation of the skin reflectance spectra when the chromatophore density and/or composition is altered, as seen in the different morphs. Our results also revealed that the guanine crystals in the Lavender morph are smaller and more irregularly shaped, whereas the melanosomes are bigger and less circular compared to the wild type. Finally, we set up a protocol for melanin extraction, that could be used for a rigorous and quantitative description of the melanin concentration present in skin patches of different morphs.