Scientific article

Non-Invasive Brain Stimulation in Dementia: A Complex Network Story

Published inNeurodegenerative Diseases, vol. 18, no. 5-6, p. 281-301
Publication date2018

Non-invasive brain stimulation (NIBS) is emerging as a promising rehabilitation tool for a number of neurodegenerative diseases. However, the therapeutic mechanisms of NIBS are not completely understood. In this review, we will summarize NIBS results in the context of brain imaging studies of functional connectivity and metabolites to gain insight into the possible mechanisms underlying recovery. We will briefly discuss how the clinical manifestations of common neurodegenerative disorders may be related with aberrant connectivity within large-scale neural networks. We will then focus on recent studies combining resting-state functional magnetic resonance imaging with NIBS to delineate how stimulation of different brain regions induce complex network modifications, both at the local and distal level. Moreover, we will review studies combining magnetic resonance spectroscopy and NIBS to investigate how microscale changes are related to modifications of large-scale networks. Finally, we will re-examine previous NIBS studies in dementia in light of this network perspective. A better understanding of NIBS impact on the functionality of large-scale brain networks may be useful to design beneficial treatments for neurodegenerative disorders.

  • Non-invasive stimulation
  • Dementia
  • Functional Connectivity
  • Resting state networks
Citation (ISO format)
PINI, Lorenzo et al. Non-Invasive Brain Stimulation in Dementia: A Complex Network Story. In: Neurodegenerative Diseases, 2018, vol. 18, n° 5-6, p. 281–301. doi: 10.1159/000495945
Main files (1)
Article (Published version)
ISSN of the journal1660-2854

Technical informations

Creation05/20/2019 4:24:00 PM
First validation05/20/2019 4:24:00 PM
Update time03/15/2023 5:10:27 PM
Status update03/15/2023 5:10:26 PM
Last indexation01/17/2024 5:37:01 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack