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Title

Light Entrains Diurnal Changes in Insulin Sensitivity of Skeletal Muscle via Ventromedial Hypothalamic Neurons

Authors
Kinouchi, Kenichiro
Liu, Yu
Ioris, Rafael M.
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Published in Cell Reports. 2019, vol. 27, no. 8, p. 2385-2398.e3
Abstract Loss of synchrony between geophysical time and insulin action predisposes to metabolic diseases. Yet the brain and peripheral pathways linking proper insulin effect to diurnal changes in light-dark and feeding-fasting inputs are poorly understood. Here, we show that the insulin sensitivity of several metabolically relevant tissues fluctuates during the 24 h period. For example, in mice, the insulin sensitivity of skeletal muscle, liver, and adipose tissue is lowest during the light period. Mechanistically, by performing loss- and gain-of-light-action and food-restriction experiments, we demonstrate that SIRT1 in steroidogenic factor 1 (SF1) neurons of the ventromedial hypothalamic nucleus (VMH) convey photic inputs to entrain the biochemical and metabolic action of insulin in skeletal muscle. These findings uncover a critical light-SF1-neuron-skeletal-muscle axis that acts to finely tune diurnal changes in insulin sensitivity and reveal a light regulatory mechanism of skeletal muscle function.
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Research group Groupe Coppari Roberto (physiologie cellulaire et métabolisme) (921)
Projects FNS: 310030_169966/1
LEPTINT1DM
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ARAS, Ebru et al. Light Entrains Diurnal Changes in Insulin Sensitivity of Skeletal Muscle via Ventromedial Hypothalamic Neurons. In: Cell Reports, 2019, vol. 27, n° 8, p. 2385-2398.e3. https://archive-ouverte.unige.ch/unige:118047

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Deposited on : 2019-05-22

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