Spectral aliasing is a methodology avoiding long experimental times that can be used as an alternative to recording experiments with incremented number of points for 2D NMR experiments when a high resolution in the F1 indirect dimension is desired. Usually, ambiguities in chemical shift in the F1 indirect dimension are introduced, making it impossible to determine the true chemical shift of the aliased signals. We have developed a new methodology that allows to resolve those ambiguities within a single experiment, encoding the missing chemical shift information along the F1 indirect dimension. Its modular conception allows to apply this new methodology to a variety of different 2D NMR experiments, such as HSQC or PSYCHE CLIP-COSY, etc. An easy-to-use reconstruction program has also been coded to automatically resolve chemical shift ambiguities and obtain the true chemical shifts of the aliased signals.