A new potent antifungal 'quinone methide' diterpene with a cassane skeleton from Bobgunnia madagascariensis

Schaller, F.; Rahalison, L.; Islam, N.; Potterat, O.; Hostettmann, Kurt; Stoeckli-Evans, H.; Mavi, S.

Scientific article

English

A new potent antifungal 'quinone methide' diterpene with a cassane skeleton from Bobgunnia madagascariensis

ContributorsSchaller, F.; Rahalison, L.; Islam, N.; Potterat, O.; Hostettmann, Kurt; Stoeckli-Evans, H.; Mavi, S.

Published inHelvetica chimica acta, vol. 83, p. 407-413

Publication date2000

Abstract

A new 'quinone methide' diterpene with a cassane skeleton was isolated from the root bark of Bobgunnia madagascariensis (DESV.) J.H. KIRKBR. et WIERSEMA (Leguminosae). Its structure was established as (4bS,8aS)-4b,5,6,7,8,8a-hexahydro-4-hydroxy-2-(2-hydroxyethyl)-1,4b,8,8-tetramethylphenathrene-3,9-dione by spectroscopic methods including single-crystal X-ray analysis. This compound showed strong antifungal properties towards human pathogenic fungi, in particular the yeast Candida albicans.

Keywords

Bobgunnia madagascariensis (DESV
Single-crystal X-ray analysis
Antifungal properties

Affiliation Not a UNIGE publication

Citation (ISO format)

SCHALLER, F. et al. A new potent antifungal “quinone methide” diterpene with a cassane skeleton from Bobgunnia madagascariensis. In: Helvetica chimica acta, 2000, vol. 83, p. 407–413.

Article (Published version)

Identifiers

PID : unige:11780

ISSN of the journal0018-019X

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A new potent antifungal 'quinone methide' diterpene with a cassane skeleton from Bobgunnia madagascariensis

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