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Control of synaptic plasticity in deep cortical networks

Roelfsema, Pieter R.
Published in Nature Reviews Neuroscience. 2018, vol. 19, no. 3, p. 166-180
Abstract Humans and many other animals have an enormous capacity to learn about sensory stimuli and to master new skills. However, many of the mechanisms that enable us to learn remain to be understood. One of the greatest challenges of systems neuroscience is to explain how synaptic connections change to support maximally adaptive behaviour. Here, we provide an overview of factors that determine the change in the strength of synapses, with a focus on synaptic plasticity in sensory cortices. We review the influence of neuromodulators and feedback connections in synaptic plasticity and suggest a specific framework in which these factors can interact to improve the functioning of the entire network.
PMID: 29449713
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Other version: http://www.nature.com/doifinder/10.1038/nrn.2018.6
Research group Les circuits neuronaux dans le néocortex des mammifères (855)
Swiss National Science Foundation: 31003A‑153448; CRSII3‑154453
Swiss National Science Foundation: SYNAPSY grant 51NF40‑158776
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ROELFSEMA, Pieter R., HOLTMAAT, Anthony. Control of synaptic plasticity in deep cortical networks. In: Nature Reviews Neuroscience, 2018, vol. 19, n° 3, p. 166-180. doi: 10.1038/nrn.2018.6 https://archive-ouverte.unige.ch/unige:117724

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Deposited on : 2019-05-17

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