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Title

Control of synaptic plasticity in deep cortical networks

Authors
Roelfsema, Pieter R.
Published in Nature Reviews Neuroscience. 2018, vol. 19, no. 3, p. 166-180
Abstract Humans and many other animals have an enormous capacity to learn about sensory stimuli and to master new skills. However, many of the mechanisms that enable us to learn remain to be understood. One of the greatest challenges of systems neuroscience is to explain how synaptic connections change to support maximally adaptive behaviour. Here, we provide an overview of factors that determine the change in the strength of synapses, with a focus on synaptic plasticity in sensory cortices. We review the influence of neuromodulators and feedback connections in synaptic plasticity and suggest a specific framework in which these factors can interact to improve the functioning of the entire network.
Identifiers
PMID: 29449713
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Article (Published version) (883 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.nature.com/doifinder/10.1038/nrn.2018.6
Structures
Research group Les circuits neuronaux dans le néocortex des mammifères (855)
Projects FNS: 31003A‑153448; CRSII3‑154453
FNS: SYNAPSY grant 51NF40‑158776
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(ISO format)
ROELFSEMA, Pieter R., HOLTMAAT, Anthony. Control of synaptic plasticity in deep cortical networks. In: Nature Reviews Neuroscience, 2018, vol. 19, n° 3, p. 166-180. doi: 10.1038/nrn.2018.6 https://archive-ouverte.unige.ch/unige:117724

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Deposited on : 2019-05-17

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