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Title

Intoxication with Calcium Channel Blockers and Other Highly Protein-Bound Drugs: Why Use MARS? Two Clinical Case Reports

Authors
Mollard, Frederic
Baud, Frederic J
Published in Journal of Clinical Toxicology. 2018, vol. 08, no. 03
Abstract Overdose with calcium channel blockers is often a life-threating condition that is frequently exacerbated by the availability of extended-release preparations with slow drug clearances. In the annual report of the American Association of Poison Control Centers, calcium channel inhibitor overdose is one of the most deadly poisonings. In addition, calcium channel blockers are highly bound to proteins, making them difficult to remove using standard dialysis techniques. We describe two cases of amlodipine overdose that presented with profound circulatory shock and were treated with the Molecular Adsorbent Recirculating System™ (MARS™). In this regard, the authors reviewed other cases reported in the literature to discuss the rationale for using albumin dialysis techniques in the setting of highly protein-bound drug intoxication.
Keywords MARSAlbumin dialysisHighly protein-bound drugsIntoxicationOverdose
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Research group Groupe de recherche en hémodynamique (913)
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GARCIA MARTINEZ, Juan José et al. Intoxication with Calcium Channel Blockers and Other Highly Protein-Bound Drugs: Why Use MARS? Two Clinical Case Reports. In: Journal of Clinical Toxicology, 2018, vol. 08, n° 03. https://archive-ouverte.unige.ch/unige:117722

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Deposited on : 2019-05-17

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