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Scientific article
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Isolation and Structure Elucidation of an Isoflavone and a Sesterterpenoic Acid from Henriettella fascicularis

Published inJournal of natural products, vol. 65, no. 12, p. 1749-1753
Publication date2002
Abstract

A new isoflavone, 4',5,7-trihydroxy-6,8-dimethylisoflavone (1), and a new sesterterpenoic acid (2), together with five known compounds, lichexanthone (3), (-)-pinoresinol (4), betulinic acid, palmitic acid, and beta-sitosterol, were isolated from a dichloromethane extract of the branches of Henriettella fascicularis. Their structures were established by extensive spectroscopic methods. An attempt to determine the absolute stereochemistry of (2E,6S)-6-[(1R,5Z,3aS,9R,10Z,12aR)-1,2,3,3a,4,7,8,9,12,12a-decahydro-9-hydroxy-3a,6,10-trimethylcyclopentanocycloundecen-1-yl]-2-methylhept-2-enoic acid (2) was performed by single-crystal X-ray analysis, using Cu Kalpha radiation. Compound 1 showed significant competitive binding to estrogen receptor beta and moderate antiestrogenic activity with cultured Ishikawa cells.

Keywords
  • Estrogen-receptor
  • Flavonoids
  • Lignans
  • Spectra
Affiliation Not a UNIGE publication
Citation (ISO format)
CALDERÓN, Angela I. et al. Isolation and Structure Elucidation of an Isoflavone and a Sesterterpenoic Acid from Henriettella fascicularis. In: Journal of natural products, 2002, vol. 65, n° 12, p. 1749–1753. doi: 10.1021/np0201164
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ISSN of the journal0163-3864
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