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Title

Immunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human
Authors
Montanari, Elisa
Gonelle-Gispert, Carmen
Seebach, Jorg Dieter
Knoll, Michael F
Bottino, Rita
Buehler, Leo Hans
Published in Transplant International. 2019
Abstract Pancreatic islet allotransplantation is a treatment for patients with severe forms of type 1 diabetes. As long-term graft function and survival are not yet optimal, additional studies are warranted in order to continue improving transplant outcomes. The mechanisms of islet graft loss and tolerance induction are often studied in murine diabetes models. Despite numerous islet transplantation studies successfully performed over recent years, translation from experimental mouse models to human clinical application remains elusive. This review aims at critically discussing the strengths and limitations of current mouse models of diabetes and experimental islet transplantation. In particular, we will analyze the causes leading to diabetes and compare the immunological mechanisms responsible for rejection between mouse and human. A better understanding of the experimental mouse models should facilitate translation to human clinical application. This article is protected by copyright. All rights reserved.
Identifiers
PMID: 31033036
Full text
Article (Accepted version) (573 Kb) - public document Free access
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research groups Cultures cellulaires et transplantations (519)
La transplantation d'îlots de Langerhans (623)
Groupe Seebach Jorg Dieter (transplantation et immunologie) (856)
Project Insuleman Foundation, the Child Foundation and the OPO Stiftung
Citation
(ISO format) 		MONTANARI, Elisa et al. Immunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human. In: Transplant International, 2019. doi: 10.1111/tri.13445 https://archive-ouverte.unige.ch/unige:116920

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Deposited on : 2019-05-03

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