Immunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human

Montanari, Elisa; Gonelle-Gispert, Carmen; Seebach, Jorg Dieter; Knoll, Michael F; Bottino, Rita; Buehler, Leo Hans

doi:10.1111/tri.13445

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Title		Immunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human
Authors		Montanari, Elisa Gonelle-Gispert, Carmen Seebach, Jorg Dieter Knoll, Michael F Bottino, Rita Buehler, Leo Hans
Published in		Transplant international. 2019
Abstract		Pancreatic islet allotransplantation is a treatment for patients with severe forms of type 1 diabetes. As long-term graft function and survival are not yet optimal, additional studies are warranted in order to continue improving transplant outcomes. The mechanisms of islet graft loss and tolerance induction are often studied in murine diabetes models. Despite numerous islet transplantation studies successfully performed over recent years, translation from experimental mouse models to human clinical application remains elusive. This review aims at critically discussing the strengths and limitations of current mouse models of diabetes and experimental islet transplantation. In particular, we will analyze the causes leading to diabetes and compare the immunological mechanisms responsible for rejection between mouse and human. A better understanding of the experimental mouse models should facilitate translation to human clinical application. This article is protected by copyright. All rights reserved.
Identifiers		DOI: 10.1111/tri.13445 PMID: 31033036
Full text		Article (Accepted version) (573 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research groups		Cultures cellulaires et transplantations (519) La transplantation d'îlots de Langerhans (623) Laboratoire d'immunologie translationnelle (856)
Project		Autre: Insuleman Foundation, the Child Foundation and the OPO Stiftung
Citation (ISO format)		MONTANARI, Elisa et al. Immunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human. In: Transplant International, 2019. doi: 10.1111/tri.13445 https://archive-ouverte.unige.ch/unige:116920