Xanthones from Gentiana campestris as New Acetylcholinesterase Inhibitors

Urbain, Aurélie; Marston, Andrew; Queiroz, Emerson Ferreira; Ndjoko Ioset, Karine; Hostettmann, Kurt

doi:10.1055/s-2004-832632

Scientific article

English

Xanthones from Gentiana campestris as New Acetylcholinesterase Inhibitors

ContributorsUrbain, Aurélie; Marston, Andrew; Queiroz, Emerson Ferreira; Ndjoko Ioset, Karine; Hostettmann, Kurt

Published inPlanta medica, vol. 70, no. 10, p. 1011-1014

Publication date2004

Abstract

In order to discover new acetylcholinesterase (AChE) inhibitors, different plant extracts were screened by a previously established TLC bioautographic method. The methanol extract of Gentiana campestris leaves exhibited significant inhibition of AChE activity. A bioactivity-guided fractionation approach was undertaken to isolate the active components. Four xanthones, bellidin, bellidifolin, bellidin 8-O-beta-glucopyranoside (norswertianolin), and bellidifolin 8-O-beta-glucopyranoside (swertianolin), were found to be responsible for the anti-AChE activity effects. Bellidifolin showed similar activity to galanthamine in this enzyme assay.

Keywords

Alzheimers-disease
Gentiana campestris
AChE activity
Xanthones

Affiliation entities

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

URBAIN, Aurélie et al. Xanthones from Gentiana campestris as New Acetylcholinesterase Inhibitors. In: Planta medica, 2004, vol. 70, n° 10, p. 1011–1014. doi: 10.1055/s-2004-832632

Article (Published version)

Identifiers

PID : unige:11684
DOI : 10.1055/s-2004-832632

Journal ISSN0032-0943

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Xanthones from Gentiana campestris as New Acetylcholinesterase Inhibitors

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