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Scientific article
English

Xanthones from Gentiana campestris as New Acetylcholinesterase Inhibitors

Published inPlanta medica, vol. 70, no. 10, p. 1011-1014
Publication date2004
Abstract

In order to discover new acetylcholinesterase (AChE) inhibitors, different plant extracts were screened by a previously established TLC bioautographic method. The methanol extract of Gentiana campestris leaves exhibited significant inhibition of AChE activity. A bioactivity-guided fractionation approach was undertaken to isolate the active components. Four xanthones, bellidin, bellidifolin, bellidin 8-O-beta-glucopyranoside (norswertianolin), and bellidifolin 8-O-beta-glucopyranoside (swertianolin), were found to be responsible for the anti-AChE activity effects. Bellidifolin showed similar activity to galanthamine in this enzyme assay.

Keywords
  • Alzheimers-disease
  • Gentiana campestris
  • AChE activity
  • Xanthones
Citation (ISO format)
URBAIN, Aurélie et al. Xanthones from Gentiana campestris as New Acetylcholinesterase Inhibitors. In: Planta medica, 2004, vol. 70, n° 10, p. 1011–1014. doi: 10.1055/s-2004-832632
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ISSN of the journal0032-0943
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