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Xanthones from Gentiana campestris as New Acetylcholinesterase Inhibitors

Marston, Andrew
Queiroz, Emerson Ferreira
Published in Planta Medica. 2004, vol. 70, no. 10, p. 1011 - 1014
Abstract In order to discover new acetylcholinesterase (AChE) inhibitors, different plant extracts were screened by a previously established TLC bioautographic method. The methanol extract of Gentiana campestris leaves exhibited significant inhibition of AChE activity. A bioactivity-guided fractionation approach was undertaken to isolate the active components. Four xanthones, bellidin, bellidifolin, bellidin 8-O-beta-glucopyranoside (norswertianolin), and bellidifolin 8-O-beta-glucopyranoside (swertianolin), were found to be responsible for the anti-AChE activity effects. Bellidifolin showed similar activity to galanthamine in this enzyme assay.
Keywords Alzheimers-diseaseGentiana campestrisAChE activityXanthones
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URBAIN, Aurélie et al. Xanthones from Gentiana campestris as New Acetylcholinesterase Inhibitors. In: Planta Medica, 2004, vol. 70, n° 10, p. 1011 - 1014. doi: 10.1055/s-2004-832632 https://archive-ouverte.unige.ch/unige:11684

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Deposited on : 2010-08-31

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