UNIGE document Scientific Article
previous document  unige:116826  next document
add to browser collection
Title

Additive manufacturing of hierarchical injectable scaffolds for tissue engineering

Authors
Piacentini, N.
Aeberli, L.
Da Silva, A.
Verheyen, C.A.
Rochat, A.
show hidden authors show all authors [1 - 11]
Published in Acta Biomaterialia. 2018, vol. 76, p. 71-79
Abstract We present a 3D-printing technology allowing free-form fabrication of centimetre-scale injectable structures for minimally invasive delivery. They result from the combination of 3D printing onto a cryogenic substrate and optimisation of carboxymethylcellulose-based cryogel inks. The resulting highly porous and elastic cryogels are biocompatible, and allow for protection of cell viability during compression for injection. Implanted into the murine subcutaneous space, they are colonized with a loose fibrovascular tissue with minimal signs of inflammation and remain encapsulation-free at three months. Finally, we vary local pore size through control of the substrate temperature during cryogenic printing. This enables control over local cell seeding density in vitro and over vascularization density in cell-free scaffolds in vivo. In sum, we address the need for 3D-bioprinting of large, yet injectable and highly biocompatible scaffolds and show modulation of the local response through control over local pore size.
Keywords 3D printingHydrogelBiocompatibleInjectableImplantationCarboxymethylcellulose
Identifiers
PMID: 29883809
Full text
Structures
Research group Groupe Thomas Braschler (970)
Projects FNS: PP00P2_163684
FNS: PZ00P2_161347
Citation
(ISO format)
BEDUER, Amélie et al. Additive manufacturing of hierarchical injectable scaffolds for tissue engineering. In: Acta Biomaterialia, 2018, vol. 76, p. 71-79. doi: 10.1016/j.actbio.2018.05.056 https://archive-ouverte.unige.ch/unige:116826

251 hits

179 downloads

Update

Deposited on : 2019-05-02

Export document
Format :
Citation style :