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Article scientifique
Accès libre
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Additive manufacturing of hierarchical injectable scaffolds for tissue engineering

Publié dansActa Biomaterialia, vol. 76, p. 71-79
Date de publication2018
Résumé

We present a 3D-printing technology allowing free-form fabrication of centimetre-scale injectable structures for minimally invasive delivery. They result from the combination of 3D printing onto a cryogenic substrate and optimisation of carboxymethylcellulose-based cryogel inks. The resulting highly porous and elastic cryogels are biocompatible, and allow for protection of cell viability during compression for injection. Implanted into the murine subcutaneous space, they are colonized with a loose fibrovascular tissue with minimal signs of inflammation and remain encapsulation-free at three months. Finally, we vary local pore size through control of the substrate temperature during cryogenic printing. This enables control over local cell seeding density in vitro and over vascularization density in cell-free scaffolds in vivo. In sum, we address the need for 3D-bioprinting of large, yet injectable and highly biocompatible scaffolds and show modulation of the local response through control over local pore size.

Mots-clés
  • 3D printing
  • Hydrogel
  • Biocompatible
  • Injectable
  • Implantation
  • Carboxymethylcellulose
Citation (format ISO)
BEDUER, Amélie et al. Additive manufacturing of hierarchical injectable scaffolds for tissue engineering. In: Acta Biomaterialia, 2018, vol. 76, p. 71–79. doi: 10.1016/j.actbio.2018.05.056
Fichiers principaux (2)
Article (Accepted version)
accessLevelPublic
Article (Published version)
accessLevelRestricted
Identifiants
ISSN du journal1742-7061
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Informations techniques

Création11/11/2018 13:43:00
Première validation11/11/2018 13:43:00
Heure de mise à jour15/03/2023 16:25:52
Changement de statut15/03/2023 16:25:51
Dernière indexation17/01/2024 05:29:24
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