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Scientific article
English

Antileishmanial and antifungal acridone derivatives from the roots of Thamnosma rhodesica

Published inPhytochemistry, vol. 65, no. 7, p. 963-968
Publication date2004
Abstract

Eight furanocoumarins, one coumarin and four acridone derivatives have been identified in the roots of Thamnosma rhodesica (Rutaceae). Rhodesiacridone, one of these acridone derivatives, is reported here for the first time. Its structure was elucidated by spectrometric methods including ESI-HR, EI, DCI mass spectrometry, H-1, C-13 and 2D NMR experiments. This novel compound showed activities against the intracellular form of a human pathogen, the protozoan parasite Leishmania major. Two known acridone related compounds, gravacridonediol and 1-hydroxy-10-methylacridone, exhibited activities against the intracellular form of the same parasite and the fungus Cladosporium cucumerinum, respectively. (C) 2004 Elsevier Ltd. All rights reserved.

Keywords
  • Thamnosma rhodesica
  • Rutaceae
  • acridone derivatives
  • Coumarins
  • furanocoumarins
  • Leishmania major
  • Cladosporium cucumerinum
Affiliation Not a UNIGE publication
Citation (ISO format)
AHUA, K.M. et al. Antileishmanial and antifungal acridone derivatives from the roots of Thamnosma rhodesica. In: Phytochemistry, 2004, vol. 65, n° 7, p. 963–968. doi: 10.1016/j.phytochem.2003.12.020
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ISSN of the journal0031-9422
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