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Title

Dibenzofurans and Pseudodepsidones from the Lichen Stereocaulon paschale Collected in Northern Quebec

Authors
Carpentier, Claudia
Queiroz, Emerson Ferreira
Azelmat, Jabrane
Grenier, Daniel
Boudreau, Stéphane
Voyer, Normand
Published in Journal of Natural Products. 2017, vol. 80, no. 1, p. 210-214
Abstract Chemical investigation of the methanol extract of the lichen Stereocaulon paschale collected in Nunavik, Canada, led to the isolation and identification of two new dibenzofurans (1 and 3) and 11 known lichen metabolites. The structures of the new compounds were established by analysis of 1D and 2D NMR spectroscopic and high-resolution mass spectrometric data. Herein, the first isolation of ascomatic acid dibenzofuran derivatives (1-3) from a whole lichen organism is reported. In addition, some of the isolated metabolites showed antibacterial activity against the oral pathogens Porphyromonas gingivalis and Streptococcus mutans.
Keywords Anti-Bacterial Agents/chemistry/isolation & purification/pharmacologyCanadaDibenzofurans/chemistry/isolation & purification/pharmacologyLichens/chemistryMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsMolecular StructurePorphyromonas gingivalis/drug effectsStreptococcus mutans
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PMID: 28079378
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Structures
Research group Phytochimie et produits naturels bioactifs
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CARPENTIER, Claudia et al. Dibenzofurans and Pseudodepsidones from the Lichen Stereocaulon paschale Collected in Northern Quebec. In: Journal of Natural Products, 2017, vol. 80, n° 1, p. 210-214. doi: 10.1021/acs.jnatprod.6b00831 https://archive-ouverte.unige.ch/unige:116651

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Deposited on : 2019-04-25

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