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Coumarins from Peucedanum ostruthium as Inhibitors of Acetylcholinesterase

Marston, Andrew
Published in Pharmaceutical biology. 2005, vol. 43, no. 8, p. 647 - 650
Abstract Different plant extracts have been screened by thin-layer chromatography (TLC) bioautography in an effort to discover new acetylcholinesterase (AChE) inhibitors. The CH2 Cl-2 extract of Peucedanum ostruthium (L.) Koch roots exhibited significant inhibition of AChE-l activity. Active constituents were isolated by bioguided fractionation using almost exclusively centrifugal partition chromatography. Four coumarins (ostruthin, imperatorin, ostruthol, and oxypeucedanin hydrate) and a chromone derivative (peucenin) were found to inhibit AChE activity in this bioassay.
Keywords Acetylcholinesterase inhibitorsBioautographyCentrifugal partition chromatographyCoumarinsPeucedanum ostruthium
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URBAIN, Aurélie, MARSTON, Andrew, HOSTETTMANN, Kurt. Coumarins from Peucedanum ostruthium as Inhibitors of Acetylcholinesterase. In: Pharmaceutical biology, 2005, vol. 43, n° 8, p. 647 - 650. doi: 10.1080/13880200500382720 https://archive-ouverte.unige.ch/unige:11665

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Deposited on : 2010-08-30

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