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Scientific article
English

Coumarins from Peucedanum ostruthium as Inhibitors of Acetylcholinesterase

Contributors

Urbain, Aurélie; Marston, Andrew; Hostettmann, Kurt

Published in

Pharmaceutical biology, vol. 43, no. 8, p. 647-650

Publication date

2005

Abstract

Different plant extracts have been screened by thin-layer chromatography (TLC) bioautography in an effort to discover new acetylcholinesterase (AChE) inhibitors. The CH2 Cl-2 extract of Peucedanum ostruthium (L.) Koch roots exhibited significant inhibition of AChE-l activity. Active constituents were isolated by bioguided fractionation using almost exclusively centrifugal partition chromatography. Four coumarins (ostruthin, imperatorin, ostruthol, and oxypeucedanin hydrate) and a chromone derivative (peucenin) were found to inhibit AChE activity in this bioassay.

Keywords

  • Acetylcholinesterase inhibitors
  • Bioautography
  • Centrifugal partition chromatography
  • Coumarins
  • Peucedanum ostruthium

UNIGE affiliation entities

Citation (ISO format)

URBAIN, Aurélie, MARSTON, Andrew, HOSTETTMANN, Kurt. Coumarins from Peucedanum ostruthium as Inhibitors of Acetylcholinesterase. In: Pharmaceutical biology, 2005, vol. 43, n° 8, p. 647–650. doi: 10.1080/13880200500382720

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1388-0209
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Technical informations

Creation

11/08/2010 11:12:00

First validation

11/08/2010 11:12:00

Update

14/03/2023 16:05:45

Status update

14/03/2023 16:05:45

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