UNIGE document Scientific Article
previous document  unige:11665  next document
add to browser collection
Title

Coumarins from Peucedanum ostruthium as Inhibitors of Acetylcholinesterase

Authors
Marston, Andrew
Published in Pharmaceutical Biology. 2005, vol. 43, no. 8, p. 647 - 650
Abstract Different plant extracts have been screened by thin-layer chromatography (TLC) bioautography in an effort to discover new acetylcholinesterase (AChE) inhibitors. The CH2 Cl-2 extract of Peucedanum ostruthium (L.) Koch roots exhibited significant inhibition of AChE-l activity. Active constituents were isolated by bioguided fractionation using almost exclusively centrifugal partition chromatography. Four coumarins (ostruthin, imperatorin, ostruthol, and oxypeucedanin hydrate) and a chromone derivative (peucenin) were found to inhibit AChE activity in this bioassay.
Keywords Acetylcholinesterase inhibitorsBioautographyCentrifugal partition chromatographyCoumarinsPeucedanum ostruthium
Identifiers
Full text
Structures
Citation
(ISO format)
URBAIN, Aurélie, MARSTON, Andrew, HOSTETTMANN, Kurt. Coumarins from Peucedanum ostruthium as Inhibitors of Acetylcholinesterase. In: Pharmaceutical Biology, 2005, vol. 43, n° 8, p. 647 - 650. https://archive-ouverte.unige.ch/unige:11665

194 hits

0 download

Update

Deposited on : 2010-08-30

Export document
Format :
Citation style :