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Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

Wang, Mingxun
Carver, Jeremy J
Phelan, Vanessa V
Sanchez, Laura M
Garg, Neha
Peng, Yao
Published in Nature Biotechnology. 2016, vol. 34, no. 8, p. 828-837
Abstract The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP community has no way to share data other than in published papers. Although mass spectrometry (MS) techniques are well-suited to high-throughput characterization of NP, there is a pressing need for an infrastructure to enable sharing and curation of data. We present Global Natural Products Social Molecular Networking (GNPS; http://gnps.ucsd.edu), an open-access knowledge base for community-wide organization and sharing of raw, processed or identified tandem mass (MS/MS) spectrometry data. In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations. Data-driven social-networking should facilitate identification of spectra and foster collaborations. We also introduce the concept of 'living data' through continuous reanalysis of deposited data.
Keywords Biological Products/chemistry/classificationData Curation/methodsDatabase Management SystemsDatabasesChemicalInformation Dissemination/methodsInformation Storage and Retrieval/methodsInternationalityMass Spectrometry/statistics & numerical data
PMID: 27504778
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Research group Phytochimie et produits naturels bioactifs
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WANG, Mingxun et al. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. In: Nature Biotechnology, 2016, vol. 34, n° 8, p. 828-837. doi: 10.1038/nbt.3597 https://archive-ouverte.unige.ch/unige:116647

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Deposited on : 2019-04-25

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