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Scientific article
Open access
English

Warming up the tumor microenvironment in order to enhance immunogenicity

Published inOncoImmunology, vol. 8, no. 1, e1510710
Publication date2019
Abstract

We have recently demonstrated that intratumoral CpG-B vaccination enhances anti-tumor immunity and tumor regression in mice. We further show that the local delivery of TLR9 agonists converts the tolerogenic tumor microenvironment into an immunopermissive one, which may benefit current immunotherapeutic anticancer strategies by enhancing innate and adaptive tumor-associated immune cell responses.

Keywords
  • Tumor microenvironment
  • Local immunotherapy
  • CpG-B
Funding
Citation (ISO format)
HUMBERT, Marion, HUGUES, Stéphanie. Warming up the tumor microenvironment in order to enhance immunogenicity. In: OncoImmunology, 2019, vol. 8, n° 1, p. e1510710. doi: 10.1080/2162402X.2018.1510710
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Article (Published version)
Identifiers
ISSN of the journal2162-4011
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Technical informations

Creation03/13/2019 1:33:00 PM
First validation03/13/2019 1:33:00 PM
Update time03/15/2023 4:23:42 PM
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