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Warming up the tumor microenvironment in order to enhance immunogenicity

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Published in OncoImmunology. 2019, vol. 8, no. 1, p. e1510710
Abstract We have recently demonstrated that intratumoral CpG-B vaccination enhances anti-tumor immunity and tumor regression in mice. We further show that the local delivery of TLR9 agonists converts the tolerogenic tumor microenvironment into an immunopermissive one, which may benefit current immunotherapeutic anticancer strategies by enhancing innate and adaptive tumor-associated immune cell responses.
Keywords Tumor microenvironmentLocal immunotherapyCpG-B
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PMID: 30546946
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Article (Published version) (448 Kb) - public document Free access
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Research group Pathologie et immunologie (906)
Projects FNS: P00P3_152951 et 310030_166541
European Research Council 281365
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HUMBERT, Marion, HUGUES, Stéphanie. Warming up the tumor microenvironment in order to enhance immunogenicity. In: OncoImmunology, 2019, vol. 8, n° 1, p. e1510710. https://archive-ouverte.unige.ch/unige:116618

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Deposited on : 2019-04-24

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