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Scientific article
English

Bio-guided isolation of cholinesterase inhibitors from the bulbs of Crinum x powellii

Published inPTR. Phytotherapy research, vol. 19, no. 11, p. 984-987
Publication date2005
Abstract

In a search for potential acetylcholinesterase (AChE) inhibitors, the ethanol extract of the bulbs of Crinum X powellii (Amaryllidaceae) was found to demonstrate a marked inhibition of this enzyme. Using a bio-guided isolation strategy, linoleic acid ethyl ester has been identified as the compound responsible for this inhibition. Three other molecules - the alkaloid hippadine, the glycosylated benzyl alcohol derivative calleryanin and 4'-hydroxy-7-methoxyflavan - were also isolated and characterized for the first time from Crinum x powellii. The structures of these compounds were elucidated by spectrometric methods including EI, D/CI mass spectrometry, H-1, C-13 and 2D NMR experiments. Linoleic acid was also found to inhibit AChE.

Keywords
  • ALZHEIMERS-DISEASE
  • AMARYLLIDACEAE
  • ACETYLCHOLINESTERASE
  • CONSTITUENTS
  • MORPHOLOGY
  • ALKALOIDS
  • PLANTS
Citation (ISO format)
KISSLING, Jonathan et al. Bio-guided isolation of cholinesterase inhibitors from the bulbs of Crinum x powellii. In: PTR. Phytotherapy research, 2005, vol. 19, n° 11, p. 984–987. doi: 10.1002/ptr.1770
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ISSN of the journal0951-418X
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