en
Scientific article
English

The role of inflammatory and parenchymal cells in acute pancreatitis

Published inJournal of pathology, vol. 213, no. 3, p. 239-248
Publication date2007
Abstract

The infiltration of inflammatory cells into the pancreas is an early and central event in acute pancreatitis that promotes local injury and systemic complications of the disease. Recent research has yielded the important finding that resident cells of the pancreas (particularly acinar and pancreatic stellate cells) play a dynamic role in leukocyte attraction via secretion of chemokines and cytokines and expression of adhesion molecules. Significant progress has been made in recent years in our understanding of the role of leukocyte movement (adhesion to the blood vessel wall, transmigration through the blood vessel wall and infiltration into the parenchyma) in the pathophysiology of acute pancreatitis. This review discusses recent studies and describes the current state of knowledge in the field. It is clear that detailed elucidation of the numerous processes in the inflammatory cascade is an essential step towards the development of improved therapeutic strategies in acute pancreatitis. Studies to date suggest that combination therapy targeting different steps of the inflammatory cascade may be the treatment of choice for this disease.

Keywords
  • Acute Disease
  • Animals
  • Cell Adhesion/physiology
  • Cell Adhesion Molecules/immunology
  • Cell Movement/physiology
  • Chemokines/immunology
  • Chemotaxis, Leukocyte
  • Extracellular Matrix/physiology
  • Humans
  • Leukocytes/immunology
  • Pancreas, Exocrine/immunology/pathology/ physiology
  • Pancreatitis/ immunology/pathology
Affiliation Not a UNIGE publication
Citation (ISO format)
VONLAUFEN, Alain et al. The role of inflammatory and parenchymal cells in acute pancreatitis. In: Journal of pathology, 2007, vol. 213, n° 3, p. 239–248. doi: 10.1002/path.2231
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ISSN of the journal0022-3417
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