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Title

Plasma Aβ42 as Biomarker of Prodromal Alzheimer's Disease Progression in Patients with Amnestic Mild Cognitive Impairment: Evidence from the PharmaCog/E-ADNI Study

Authors
Albani, Diego
Ferrari, Clarissa
Fusco, Federica
Boeri, Lucia
Raimondi, Ilaria
Jovicich, Jorge
Babiloni, Claudio
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Published in Journal of Alzheimer's Disease. 2018
Abstract It is an open issue whether blood biomarkers serve to diagnose Alzheimer's disease (AD) or monitor its progression over time from prodromal stages. Here, we addressed this question starting from data of the European FP7 IMI-PharmaCog/E-ADNI longitudinal study in amnesic mild cognitive impairment (aMCI) patients including biological, clinical, neuropsychological (e.g., ADAS-Cog13), neuroimaging, and electroencephalographic measures. PharmaCog/E-ADNI patients were classified as "positive" (i.e., "prodromal AD" n = 76) or "negative" (n = 52) based on a diagnostic cut-off of Aβ42/P-tau in cerebrospinal fluid as well as APOE ε 4 genotype. Blood was sampled at baseline and at two follow-ups (12 and 18 months), when plasma amyloid peptide 42 and 40 (Aβ42, Aβ40) and apolipoprotein J (clusterin, CLU) were assessed. Linear Mixed Models found no significant differences in plasma molecules between the "positive" (i.e., prodromal AD) and "negative" groups at baseline. In contrast, plasma Aβ42 showed a greater reduction over time in the prodromal AD than the "negative" aMCI group (p = 0.048), while CLU and Aβ40 increased, but similarly in the two groups. Furthermore, plasma Aβ42 correlated with the ADAS-Cog13 score both in aMCI patients as a whole and the prodromal AD group alone. Finally, CLU correlated with the ADAS-Cog13 only in the whole aMCI group, and no association with ADAS-Cog13 was found for Aβ40. In conclusion, plasma Aβ42 showed disease progression-related features in aMCI patients with prodromal AD.
Keywords Amnesic mild cognitive impairmentAmyloid-beta peptideBiomarkersClinical trialClusterinPharmaCog 62 projectProdromal Alzheimer’s disease
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PMID: 30149449
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Article (Published version) (350 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Troubles de mémoire et maladie d'Alzeimer (935)
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ALBANI, Diego et al. Plasma Aβ42 as Biomarker of Prodromal Alzheimer's Disease Progression in Patients with Amnestic Mild Cognitive Impairment: Evidence from the PharmaCog/E-ADNI Study. In: Journal of Alzheimer's Disease, 2018. doi: 10.3233/JAD-180321 https://archive-ouverte.unige.ch/unige:116118

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Deposited on : 2019-04-10

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