en
Proceedings chapter
English

Human genetic variation and its impact on public health and medicine

Published inEvolution in health and disease, Editors Stearns, Stephen C., p. 62-74
Presented at Sion, 6-12 April 1997
PublisherOxford : Oxford University Press
Publication date1999
Abstract

Molecular and genetic approaches now provide powerful tools for investigating the origin of human populations and the evolution of genes affecting both complex and monogenic traits. This allows a biologically appropriate classification of individuals and population groups based on genotypes and gene frequencies rather than appearance; this information will facilitate disease risk assessment. Many of the observed differences in gene frequencies between human populations may be accounted for by population movements, and it is difficult to assess how large a role natural selection has played in population differentiation. For several disease genes there is evidence that environmental agents, such as infectious pathogens, dietary factors, and environmental toxins, have been responsible for an increased frequency in some populations. Further examples of such selection may emerge from current efforts to define the genetic basis of many polygenic common diseases. We need more information on molecular genetic differences between human populations; we could obtain that information from the successful completion of the Human Genome Project and the proposed Human Genome Diversity Project.

Citation (ISO format)
HILL, Adrian V.S. et al. Human genetic variation and its impact on public health and medicine. In: Evolution in health and disease. Sion. Oxford : Oxford University Press, 1999. p. 62–74.
Main files (1)
Proceedings chapter (Published version)
accessLevelRestricted
Identifiers
  • PID : unige:116046
ISBN0198501102
238views
2downloads

Technical informations

Creation04/05/2019 2:23:00 PM
First validation04/05/2019 2:23:00 PM
Update time03/15/2023 4:20:10 PM
Status update03/15/2023 4:20:08 PM
Last indexation01/17/2024 5:20:00 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack