UNIGE document Scientific Article
previous document  unige:116037  next document
add to browser collection

An Extensive Analysis of Y-Chromosomal Microsatellite Haplotypes in Globally Dispersed Human Populations

Kayser, Manfred
Krawczak, Michael
Dieltjes, Patrick
Corach, Daniel
Pascali, Vincente
Gehrig, Christian
Bernini, Luigi F.
show hidden authors show all authors [1 - 12]
Published in American Journal of Human Genetics. 2001, vol. 68, no. 4, p. 990-1018
Abstract The genetic variance at seven Y-chromosomal microsatellite loci (or short tandem repeats [STRs]) was studied among 986 male individuals from 20 globally dispersed human populations. A total of 598 different haplotypes were observed, of which 437 (73.1%) were each found in a single male only. Population-specific haplotype-diversity values were .86–.99. Analyses of haplotype diversity and population-specific haplotypes revealed marked population-structure differences between more-isolated indigenous populations (e.g., Central African Pygmies or Greenland Inuit) and more-admixed populations (e.g., Europeans or Surinamese). Furthermore, male individuals from isolated indigenous populations shared haplotypes mainly with male individuals from their own population. By analysis of molecular variance, we found that 76.8% of the total genetic variance present among these male individuals could be attributed to genetic differences between male individuals who were members of the same population. Haplotype sharing between populations, ϕST statistics, and phylogenetic analysis identified close genetic affinities among European populations and among New Guinean populations. Our data illustrate that Y-chromosomal STR haplotypes are an ideal tool for the study of the genetic affinities between groups of male subjects and for detection of population structure.
Full text
(ISO format)
KAYSER, Manfred et al. An Extensive Analysis of Y-Chromosomal Microsatellite Haplotypes in Globally Dispersed Human Populations. In: American Journal of Human Genetics, 2001, vol. 68, n° 4, p. 990-1018. doi: 10.1086/319510 https://archive-ouverte.unige.ch/unige:116037

167 hits



Deposited on : 2019-04-10

Export document
Format :
Citation style :