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Central nervous system graft-versus-host disease (CNS-GvHD) after allogeneic haematopoietic stem cell transplantation

Published in BMJ case reports. 2018
Abstract A 60-year-old man presented with impaired consciousness and psychomotor agitation after a second allogeneic haematopoietic stem cell transplantation (HSCT) from a matched unrelated donor for acute myeloid leukaemia. Clinical, biological and radiological evidence suggested a diagnosis of central nervous system graft-versus-host disease (CNS-GvHD). After intrathecal infusion of methylprednisolone, the clinical symptoms as well as the radiological abnormalities disappeared. The present report illustrates the difficulties in the diagnosis and the management of CNS-GvHD, a very rare and still challenging neurological complication that can occur after allogeneic HSCT.
Keywords Central Nervous System/immunologyGraft vs Host Disease/drug therapy/etiology/immunologyHematopoietic Stem Cell Transplantation/adverse effectsHumansInjections, SpinalLeukemia, Myeloid, Acute/immunology/therapyMaleMethylprednisolone/administration & dosageMiddle AgedTreatment Outcome
PMID: 29330269
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Article (Published version) (582 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
Optimisations des techniques avancés en neuroimagerie (985)
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POLCHLOPEK, Karolina et al. Central nervous system graft-versus-host disease (CNS-GvHD) after allogeneic haematopoietic stem cell transplantation. In: BMJ Case Reports, 2018. doi: 10.1136/bcr-2017-221840 https://archive-ouverte.unige.ch/unige:115919

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Deposited on : 2019-04-09

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