Central nervous system graft-versus-host disease (CNS-GvHD) after allogeneic haematopoietic stem cell transplantation

Polchlopek, Karolina; Simonetta, Federico; Vargas Gomez, Maria Isabel; Chalandon, Yves

doi:10.1136/bcr-2017-221840

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Title		Central nervous system graft-versus-host disease (CNS-GvHD) after allogeneic haematopoietic stem cell transplantation
Authors		Polchlopek, Karolina Simonetta, Federico Vargas Gomez, Maria Isabel Chalandon, Yves
Published in		BMJ case reports. 2018
Abstract		A 60-year-old man presented with impaired consciousness and psychomotor agitation after a second allogeneic haematopoietic stem cell transplantation (HSCT) from a matched unrelated donor for acute myeloid leukaemia. Clinical, biological and radiological evidence suggested a diagnosis of central nervous system graft-versus-host disease (CNS-GvHD). After intrathecal infusion of methylprednisolone, the clinical symptoms as well as the radiological abnormalities disappeared. The present report illustrates the difficulties in the diagnosis and the management of CNS-GvHD, a very rare and still challenging neurological complication that can occur after allogeneic HSCT.
Keywords		Central Nervous System/immunology — Graft vs Host Disease/drug therapy/etiology/immunology — Hematopoietic Stem Cell Transplantation/adverse effects — Humans — Injections, Spinal — Leukemia, Myeloid, Acute/immunology/therapy — Male — Methylprednisolone/administration & dosage — Middle Aged — Treatment Outcome
Identifiers		DOI: 10.1136/bcr-2017-221840 PMID: 29330269
Full text		Article (Published version) (582 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research groups		Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982) Optimisations des techniques avancés en neuroimagerie (985)
Citation (ISO format)		POLCHLOPEK, Karolina et al. Central nervous system graft-versus-host disease (CNS-GvHD) after allogeneic haematopoietic stem cell transplantation. In: BMJ Case Reports, 2018. doi: 10.1136/bcr-2017-221840 https://archive-ouverte.unige.ch/unige:115919