en
Scientific article
Case report
English

Central nervous system graft-versus-host disease (CNS-GvHD) after allogeneic haematopoietic stem cell transplantation

Published inBMJ Case Reports
Publication date2018
Abstract

A 60-year-old man presented with impaired consciousness and psychomotor agitation after a second allogeneic haematopoietic stem cell transplantation (HSCT) from a matched unrelated donor for acute myeloid leukaemia. Clinical, biological and radiological evidence suggested a diagnosis of central nervous system graft-versus-host disease (CNS-GvHD). After intrathecal infusion of methylprednisolone, the clinical symptoms as well as the radiological abnormalities disappeared. The present report illustrates the difficulties in the diagnosis and the management of CNS-GvHD, a very rare and still challenging neurological complication that can occur after allogeneic HSCT.

Keywords
  • Central Nervous System/immunology
  • Graft vs Host Disease/drug therapy/etiology/immunology
  • Hematopoietic Stem Cell Transplantation/adverse effects
  • Humans
  • Injections, Spinal
  • Leukemia, Myeloid, Acute/immunology/therapy
  • Male
  • Methylprednisolone/administration & dosage
  • Middle Aged
  • Treatment Outcome
Citation (ISO format)
POLCHLOPEK, Karolina et al. Central nervous system graft-versus-host disease (CNS-GvHD) after allogeneic haematopoietic stem cell transplantation. In: BMJ Case Reports, 2018. doi: 10.1136/bcr-2017-221840
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Article (Published version)
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Identifiers
ISSN of the journal1757-790X
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Creation11/23/2018 3:06:00 PM
First validation11/23/2018 3:06:00 PM
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