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Titles listCentral nervous system graft-versus-host disease (CNS-GvHD) after allogeneic haematopoietic stem cell...
Titles listCentral nervous system graft-versus-host disease (CNS-GvHD) after allogeneic haematopoietic stem cell...
Scientific Article
unige:115919 
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Central nervous system graft-versus-host disease (CNS-GvHD) after allogeneic haematopoietic stem cell transplantation |
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| Authors | ||
| Published in | BMJ Case Reports. 2018 | |
| Abstract | A 60-year-old man presented with impaired consciousness and psychomotor agitation after a second allogeneic haematopoietic stem cell transplantation (HSCT) from a matched unrelated donor for acute myeloid leukaemia. Clinical, biological and radiological evidence suggested a diagnosis of central nervous system graft-versus-host disease (CNS-GvHD). After intrathecal infusion of methylprednisolone, the clinical symptoms as well as the radiological abnormalities disappeared. The present report illustrates the difficulties in the diagnosis and the management of CNS-GvHD, a very rare and still challenging neurological complication that can occur after allogeneic HSCT. | |
| Keywords | Central Nervous System/immunology — Graft vs Host Disease/drug therapy/etiology/immunology — Hematopoietic Stem Cell Transplantation/adverse effects — Humans — Injections, Spinal — Leukemia, Myeloid, Acute/immunology/therapy — Male — Methylprednisolone/administration & dosage — Middle Aged — Treatment Outcome | |
| Identifiers | PMID: 29330269 | |
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| Research group | Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982) | |
| Citation (ISO format) | POLCHLOPEK BLASIAK, Karolina et al. Central nervous system graft-versus-host disease (CNS-GvHD) after allogeneic haematopoietic stem cell transplantation. In: BMJ Case Reports, 2018. https://archive-ouverte.unige.ch/unige:115919 |
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