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Scientific article
English

Clinical Pharmacology in HIV Therapy

Published inClinical Journal of the American Society of Nephrology, vol. 14, no. 3, p. 435-444
Publication date2019
Abstract

The success of combination antiretroviral therapy in the treatment of HIV-1-positive individuals has shifted clinical attention toward combination antiretroviral drug regimens that optimize tolerability, long-term safety, and durable efficacy. Wherever patients have access to treatment, morbidity and mortality are increasingly driven by non-HIV-associated comorbidities, which may be observed earlier than in age-matched controls and despite the best available combination antiretroviral therapy. Similarly, HIV-1-positive individuals are now diagnosed and treated earlier with anticipated lifelong therapy. The contribution of specific antiretroviral agents to long-term morbidity and mortality is dependent on the pharmacologic characteristics of these agents, and it is increasingly important in this context.

Citation (ISO format)
ATTA, Mohamed G, DE SEIGNEUX MATTHEY, Sophie, LUCAS, Gregory M. Clinical Pharmacology in HIV Therapy. In: Clinical Journal of the American Society of Nephrology, 2019, vol. 14, n° 3, p. 435–444. doi: 10.2215/CJN.02240218
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ISSN of the journal1555-9041
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Creation11/16/2018 8:31:00 AM
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