UNIGE document Scientific Article
previous document  unige:11565  next document
add to browser collection
Title

Genetic basis of murine lupus

Authors
Laporte, Catherine
Reininger, Luc
Published in Autoimmunity Reviews. 2004, vol. 3, no. 1, p. 33-39
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by the formation of a variety of autoantibodies and subsequent development of severe glomerulonephritis. Etiology of SLE remains unknown even if it is now well established that SLE is under polygenic control as well as the contribution of hormonal and environmental factors. The availability of several murine strains that spontaneously develop an autoimmune syndrome resembling human SLE, such as New Zealand, MRL and BXSB mice has provided useful tools for the genetic dissection of susceptibility to SLE. Moreover, development of various transgenic and mutant mice has made it possible to identify a number of susceptibility genes such as those involved in the regulation of apoptosis or B cell receptor signaling that can trigger lupus-like phenotypes. Obviously, further identification of the genetic defects present in lupus-prone mice is of paramount importance for understanding the immunopathogenesis of SLE.
Keywords AnimalsAutoimmune Diseases/genetics*Autoimmunity*Disease Models, AnimalHumans*Linkage (Genetics)Lupus Erythematosus, Systemic/*geneticsLupus Nephritis/*geneticsMiceMice, Inbred MRL lprMice, Inbred NZB
Identifiers
PMID: 14871647
Full text
Structures
Citation
(ISO format)
SANTIAGO-RABER, Marie-Laure et al. Genetic basis of murine lupus. In: Autoimmunity Reviews, 2004, vol. 3, n° 1, p. 33-39. https://archive-ouverte.unige.ch/unige:11565

173 hits

0 download

Update

Deposited on : 2010-08-27

Export document
Format :
Citation style :