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Scientific article
English

A novel locus regulates both retroviral glycoprotein 70 and anti-glycoprotein 70 antibody production in New Zealand mice when crossed with BALB/c

Published inThe Journal of immunology, vol. 172, no. 8, p. 5078-5085
Publication date2004
Abstract

Lupus-prone New Zealand Black and New Zealand White mice produce high serum levels of the endogenous retroviral envelope protein gp70 and develop an Ab response to this autoantigen as part of their autoimmune disease. Linkage analysis of two crosses involving New Zealand and BALB/c mice mapped these traits to a group of overlapping loci, including a novel locus on proximal chromosome 12. This locus was linked with serum gp70 and the autoimmune response against it. The linkage of serum gp70 levels to a previously described locus on distal chromosome 4 was also confirmed. Sequence analysis of a candidate gene on distal chromosome 4, Fv1, provided support that this gene may be associated with the control of serum gp70 levels in both New Zealand Black and New Zealand White mice. Linkage data and statistical analysis confirmed a close correlation between gp70 Ag and anti-gp70 Ab levels, and together gave support to the concept that a threshold level of gp70 is required for the production of anti-gp70 Abs. Serum levels of anti-gp70 Abs were closely correlated with the presence of renal disease, more so than anti-dsDNA Abs. Understanding the genetic basis of this complex autoantigen-autoantibody system will provide insight into the pathogenesis of lupus in mice, which may have implications for human disease.

Keywords
  • Animals
  • Antibodies, Viral/*biosynthesis/blood
  • Chromosome Mapping
  • Crosses, Genetic
  • Female
  • Gene Expression Regulation/*immunology
  • Genetic Markers/*immunology
  • Genetic Predisposition to Disease
  • Glomerulonephritis/genetics/immunology
  • Glycoproteins/blood/*immunology
  • Linkage (Genetics)
  • Mice
  • Mice, Congenic
  • Mice, Inbred BALB C
  • Mice, Inbred NZB
  • Proteins/genetics
  • Retroviridae/*immunology
  • Species Specificity
  • Viral Envelope Proteins/blood/*immunology
Affiliation Not a UNIGE publication
Citation (ISO format)
RIGBY, R. J. et al. A novel locus regulates both retroviral glycoprotein 70 and anti-glycoprotein 70 antibody production in New Zealand mice when crossed with BALB/c. In: The Journal of immunology, 2004, vol. 172, n° 8, p. 5078–5085. doi: 10.4049/jimmunol.172.8.5078
Updates (1)
Article
accessLevelRestricted
Identifiers
ISSN of the journal0022-1767
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