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Scientific article
English

The effects of antibiotic cycling and mixing on antibiotic resistance in intensive care units: a cluster-randomised crossover trial

Published inThe Lancet Infectious Diseases, vol. 18, no. 4, p. 401-409
Publication date2018
Abstract

Whether antibiotic rotation strategies reduce prevalence of antibiotic-resistant, Gram-negative bacteria in intensive care units (ICUs) has not been accurately established. We aimed to assess whether cycling of antibiotics compared with a mixing strategy (changing antibiotic to an alternative class for each consecutive patient) would reduce the prevalence of antibiotic-resistant, Gram-negative bacteria in European intensive care units (ICUs).

Citation (ISO format)
VAN DUIJN, Pleun Joppe et al. The effects of antibiotic cycling and mixing on antibiotic resistance in intensive care units: a cluster-randomised crossover trial. In: The Lancet Infectious Diseases, 2018, vol. 18, n° 4, p. 401–409. doi: 10.1016/S1473-3099(18)30056-2
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ISSN of the journal1473-3099
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