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Title

Neurodegenerative cerebrospinal fluid biomarkers tau and amyloid beta predict functional, quality of life, and neuropsychological outcomes after aneurysmal subarachnoid hemorrhage

Authors
Joswig, Holger
Korte, Wolfgang
Früh, Severin
Epprecht, Lorenz
Hildebrandt, Gerhard
Published in Neurosurgical Review. 2018, vol. 41, no. 2, p. 605-614
Abstract Cerebrospinal fluid (CSF) biomarkers might be useful in predicting outcome after aneurysmal subarachnoid hemorrhage (aSAH). It was the aim to determine whether tau and amyloid beta CSF concentrations predict functional, health-related quality of life (hrQoL), and neuropsychological outcomes after aSAH. Ventricular CSF was obtained from n = 24 aSAH patients at admission (D0), day 2 (D2), and day 6 (D6). CSF total (t)Tau, phosphorylated (p)Tau(181P), and amyloid beta(1-40 and 1-42) (Aβ40/Aβ42) levels were compared between patients with favorable and unfavorable functional (modified Rankin Scale (mRS)), hrQoL (Euro-Qol (EQ-5D)), and neuropsychological outcomes at 3 (3 m) and 12 months (12 m). Patients with unfavorable functional (mRS 4-6) and hrQoL outcome (EQ-5D z-score ≤ - 1.0) at 3 and 12 m had higher CSF tTau/pTau and lower Aβ40/Aβ42 at D0, D2, and D6 with varying degrees of statistical significance. In terms of predicting neuropsychological outcome, CSF pTau showed a statistically significant correlation with the z-scores of executive function (r = - 0.7486, p = 0.008), verbal memory (r = - 0.8101, p = 0.002), attention (r = - 0.6498, p = 0.030), and visuospatial functioning (r = - 0.6944, p = 0.017) at 3 m. At 12 m, CSF pTau had statistically significant correlations with the z-scores of verbal memory (r = - 0.7473, p = 0.008) and visuospatial functioning (r = - 0.6678, p = 0.024). In conclusion, higher tTau/pTau and lower Aβ40/Aβ42 CSF levels predict unfavorable long-term functional and hrQoL outcomes. Neuropsychological deficits correlate with increased CSF tTau and pTau concentrations.
Keywords AgedAmyloid beta-Peptides/cerebrospinal fluidBiomarkers/cerebrospinal fluidFemaleHumansMaleMiddle AgedPeptide FragmentsPredictive Value of TestsQuality of LifeRecovery of FunctionSubarachnoid Hemorrhage/cerebrospinal fluid/complications/psychologyTime FactorsTreatment Outcometau Proteins/cerebrospinal fluid
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PMID: 28890998
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Article (Published version) (1.3 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Groupe Schaller Karl Lothard (neurochirurgie) (851)
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JOSWIG, Holger et al. Neurodegenerative cerebrospinal fluid biomarkers tau and amyloid beta predict functional, quality of life, and neuropsychological outcomes after aneurysmal subarachnoid hemorrhage. In: Neurosurgical Review, 2018, vol. 41, n° 2, p. 605-614. https://archive-ouverte.unige.ch/unige:115370

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Deposited on : 2019-03-26

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