Guidelines for pain management in the medical and surgical departments of the Geneva University Hospitals (GUH) have been systematically developed using a multidisciplinary approach. These guidelines are aimed towards improving healthcare quality. We point to the ways the pain network of the GUH has elected to deal with the ever-increasing progression of concepts regarding pain management. This is of importance at a time when the risks related to the patients' transitions between the different departments, to the specificities of the clinical practices, and to the need for personalized care have never been so high.