Although preventive measures against the transmission of multidrug-resistant organisms (MDROs) are well established and protocolized in hospital settings, their implementation in private ambulatory practice are rarely addressed. Despite what is sometimes communicated, the risk of transmission of this type of bacteria outside of a hospital environment is real. Standard precautions are the key to minimizing this risk. In a number of situations in the ambulatory setting, MDRO screening (nasal or rectal) is needed and recommended. A system of communication among healthcare professionals concerning patients known to be carriers of MDROs should also be one of the strategies aimed at reducing the spread of these threatening bacteria throughout the health system.