en
Scientific article
English

Incidence and outcome of invasive fungal diseases after allogeneic hematopoietic stem cell transplantation: A Swiss transplant cohort study

Published inTransplant Infectious Disease, e12981
Publication date2018
Abstract

Contemporary, comprehensive data on epidemiology and outcomes of invasive fungal disease (IFD) including breakthrough IFD among allogeneic hematopoietic stem cell transplantation (HSCT) recipients are scarce. We included 479 allogeneic HSCT recipients with 10 invasive candidiasis (IC) and 31 probable/proven invasive mold disease (IMD) from the Swiss Transplant Cohort Study from 01.2009 to 08.2013. Overall cumulative incidence was 2.3% for IC and 8.5% for probable/proven IMI: 6% for invasive aspergillosis (IA) and 2.5% for non-AspergillusIMI. Among 41 IFD, 46% IFD were breakthrough, with an overall incidence of 4.6%, more frequently caused by other-than-Aspergillus fumigatus molds than primary IFD (47.6% (10/21) vs 13% (3/23), P = 0.04). Twelve-week mortality among patients with IC was 20% and 58.6% for probable/proven IMD (60% IA and 54.6% non-Aspergillus). Our results reveal that breakthrough IFD represent a marked burden of probable/proven IFD postallogeneic HSCT and mortality remains above 50% in patients with probable/proven IMD, underscoring the ongoing challenges to prevent and treat IFD in these patients.

Citation (ISO format)
KUSTER, Sabine et al. Incidence and outcome of invasive fungal diseases after allogeneic hematopoietic stem cell transplantation: A Swiss transplant cohort study. In: Transplant Infectious Disease, 2018, p. e12981. doi: 10.1111/tid.12981
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1398-2273
379views
0downloads

Technical informations

Creation11/23/2018 2:41:00 PM
First validation11/23/2018 2:41:00 PM
Update time03/15/2023 4:02:13 PM
Status update03/15/2023 4:02:11 PM
Last indexation01/17/2024 5:10:37 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack