Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations

Prunotto, Marco; Bacchetta, Marc; Jayaraman, Swaminathan; Galloni, Marco; Van Eys, Guillaume; Gabbiani, Giulio; Bochaton-Piallat, Marie-Luce

doi:10.1016/j.febslet.2007.11.060

Scientific article

English

Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations

ContributorsPrunotto, Marco; Bacchetta, Marc; Jayaraman, Swaminathan; Galloni, Marco; Van Eys, Guillaume; Gabbiani, Giulio; Bochaton-Piallat, Marie-Luce

Published inFEBS letters, vol. 581, no. 30, p. 5847-5851

Publication date2007

Abstract

We studied the effects of cytostatic drugs on porcine coronary artery spindle-shaped (S) and rhomboid (R) smooth muscle cell (SMC) biological activities related to intimal thickening (IT) formation. Imatinib, and to a lesser extent curcumin, decreased proliferation of S- and R-SMCs and migratory and urokinase activities of R-SMCs more efficiently compared with cyclosporine plus rapamycin. Imatinib increased the expression of alpha-smooth muscle actin in both SMC populations and that of smoothelin in S-SMCs. It decreased S100A4 expression in R-SMCs. By promoting SMC quiescence and differentiation imatinib and curcumin may represent valid candidates for restenosis preventive and therapeutic strategies.

Keywords

Animals
Biological Markers/metabolism
Cell Differentiation/drug effects
Cell Movement/drug effects
Cell Proliferation/drug effects
Coronary Vessels/ cytology/ drug effects/enzymology
Cytostatic Agents/ pharmacology
Immunoblotting
Myocytes, Smooth Muscle/ cytology/ drug effects/enzymology
Phenotype
S100 Proteins/metabolism
Swine
Urokinase-Type Plasminogen Activator/metabolism

Affiliation

Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Citation (ISO format)

PRUNOTTO, Marco et al. Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations. In: FEBS letters, 2007, vol. 581, n° 30, p. 5847–5851. doi: 10.1016/j.febslet.2007.11.060

Article

Identifiers

PID : unige:11528
DOI : 10.1016/j.febslet.2007.11.060
PMID : 18053813

Commercial URLhttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T36-4R7MD5M-2-N&_cdi=4938&_user=779890&_pii=S0014579307012112&_orig=search&_coverDate=12%2F22%2F2007&_sk=994189969&view=c&wchp=dGLzVzz-zSkWA&md5=26fc321c8705b2f83a3f182c5193f1af&ie=/sdarticle.pdf

ISSN of the journal0014-5793

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Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations

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