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Scientific article
English

Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations

Published inFEBS letters, vol. 581, no. 30, p. 5847-5851
Publication date2007
Abstract

We studied the effects of cytostatic drugs on porcine coronary artery spindle-shaped (S) and rhomboid (R) smooth muscle cell (SMC) biological activities related to intimal thickening (IT) formation. Imatinib, and to a lesser extent curcumin, decreased proliferation of S- and R-SMCs and migratory and urokinase activities of R-SMCs more efficiently compared with cyclosporine plus rapamycin. Imatinib increased the expression of alpha-smooth muscle actin in both SMC populations and that of smoothelin in S-SMCs. It decreased S100A4 expression in R-SMCs. By promoting SMC quiescence and differentiation imatinib and curcumin may represent valid candidates for restenosis preventive and therapeutic strategies.

Keywords
  • Animals
  • Biological Markers/metabolism
  • Cell Differentiation/drug effects
  • Cell Movement/drug effects
  • Cell Proliferation/drug effects
  • Coronary Vessels/ cytology/ drug effects/enzymology
  • Cytostatic Agents/ pharmacology
  • Immunoblotting
  • Myocytes, Smooth Muscle/ cytology/ drug effects/enzymology
  • Phenotype
  • S100 Proteins/metabolism
  • Swine
  • Urokinase-Type Plasminogen Activator/metabolism
Citation (ISO format)
PRUNOTTO, Marco et al. Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations. In: FEBS letters, 2007, vol. 581, n° 30, p. 5847–5851. doi: 10.1016/j.febslet.2007.11.060
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ISSN of the journal0014-5793
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