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Title

Release of pig leukocytes and reduced human NK cell recruitment during ex vivo perfusion of HLA-E/human CD46 double-transgenic pig limbs with human blood

Authors
Bongoni, Anjan K
Sfriso, Riccardo
Ayares, David L
Wolf, Eckhard
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Published in Xenotransplantation. 2018, vol. 25, no. 1
Abstract In pig-to-human xenotransplantation, interactions between human natural killer (NK) cells and porcine endothelial cells (pEC) are characterized by recruitment and cytotoxicity. Protection from xenogeneic NK cytotoxicity can be achieved in vitro by the expression of the non-classical human leukocyte antigen-E (HLA-E) on pEC. Thus, the aim of this study was to analyze NK cell responses to vascularized xenografts using an ex vivo perfusion system of pig limbs with human blood.
Keywords AnimalsAnimals, Genetically Modified/immunologyCytotoxicity, Immunologic/immunologyEndothelial Cells/immunologyExtremities/blood supplyHLA Antigens/geneticsHeterografts/immunologyHistocompatibility Antigens Class I/geneticsHumansKiller Cells, Natural/immunologyLeukocytes/metabolismLeukocytes, Mononuclear/immunologyMembrane Cofactor Protein/genetics/immunologyTransplantation, Heterologous/methods
Identifiers
PMID: 29057510
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Structures
Research group Groupe Seebach Jorg Dieter (transplantation et immunologie) (856)
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(ISO format)
PUGA YUNG, Gisella et al. Release of pig leukocytes and reduced human NK cell recruitment during ex vivo perfusion of HLA-E/human CD46 double-transgenic pig limbs with human blood. In: Xenotransplantation, 2018, vol. 25, n° 1. doi: 10.1111/xen.12357 https://archive-ouverte.unige.ch/unige:115267

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Deposited on : 2019-03-25

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