Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood

Abicht, Jan-Michael; Sfriso, Riccardo; Reichart, Bruno; Längin, Matthias; Gahle, Katja; Puga Yung, Gisella; Seebach, Jorg Dieter; Rieben, Robert; Ayares, David; Wolf, Eckhard; Klymiuk, Nikolai; Baehr, Andrea; Kind, Alexander; Mayr, Tanja; Bauer, Andreas

doi:10.1111/xen.12390

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Title		Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood
Authors		Abicht, Jan-Michael Sfriso, Riccardo Reichart, Bruno Längin, Matthias Gahle, Katja Puga Yung, Gisella Seebach, Jorg Dieter Rieben, Robert Ayares, David Wolf, Eckhard Klymiuk, Nikolai Baehr, Andrea Kind, Alexander Mayr, Tanja Bauer, Andreas show all authors [1 - 15]
Published in		Xenotransplantation. 2018, vol. 25, no. 5, e12390
Abstract		In pig-to-human xenotransplantation, early cellular rejection reactions are mediated by natural killer cells (NK cells). Human NK cells are inhibited by HLA-E via CD94/NKG2A receptors. To protect porcine grafts against human NK cell responses, transgenic GTKO pigs expressing hCD46 and HLA-E have been generated. The aim of this study was to test the effect of this genetic modification on xenogeneic, and in particular human NK cell response, using an ex vivo perfusion model of pig hearts with human blood.
Identifiers		DOI: 10.1111/xen.12390 PMID: 29536572
Full text		Article (Published version) (1.7 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Laboratoire d'immunologie translationnelle (856)
Citation (ISO format)		ABICHT, Jan-Michael et al. Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood. In: Xenotransplantation, 2018, vol. 25, n° 5, p. e12390. doi: 10.1111/xen.12390 https://archive-ouverte.unige.ch/unige:115263