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Title

Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood

Authors
Abicht, Jan-Michael
Sfriso, Riccardo
Reichart, Bruno
Längin, Matthias
Gahle, Katja
Rieben, Robert
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Published in Xenotransplantation. 2018, vol. 25, no. 5, p. e12390
Abstract In pig-to-human xenotransplantation, early cellular rejection reactions are mediated by natural killer cells (NK cells). Human NK cells are inhibited by HLA-E via CD94/NKG2A receptors. To protect porcine grafts against human NK cell responses, transgenic GTKO pigs expressing hCD46 and HLA-E have been generated. The aim of this study was to test the effect of this genetic modification on xenogeneic, and in particular human NK cell response, using an ex vivo perfusion model of pig hearts with human blood.
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PMID: 29536572
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Research group Groupe Seebach Jorg Dieter (transplantation et immunologie) (856)
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ABICHT, Jan-Michael et al. Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood. In: Xenotransplantation, 2018, vol. 25, n° 5, p. e12390. doi: 10.1111/xen.12390 https://archive-ouverte.unige.ch/unige:115263

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Deposited on : 2019-03-25

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