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Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood

ContributorsAbicht, Jan-Michael; Sfriso, Riccardo; Reichart, Bruno; Längin, Matthias; Gahle, Katja; Puga Yung, Gisellaorcid; Seebach, Jorg Dieter; Rieben, Robert; Ayares, David; Wolf, Eckhard; Klymiuk, Nikolai; Baehr, Andrea; Kind, Alexander; Mayr, Tanja; Bauer, Andreas
Published inXenotransplantation, vol. 25, no. 5, e12390
Publication date2018
Abstract

In pig-to-human xenotransplantation, early cellular rejection reactions are mediated by natural killer cells (NK cells). Human NK cells are inhibited by HLA-E via CD94/NKG2A receptors. To protect porcine grafts against human NK cell responses, transgenic GTKO pigs expressing hCD46 and HLA-E have been generated. The aim of this study was to test the effect of this genetic modification on xenogeneic, and in particular human NK cell response, using an ex vivo perfusion model of pig hearts with human blood.

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ABICHT, Jan-Michael et al. Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood. In: Xenotransplantation, 2018, vol. 25, n° 5, p. e12390. doi: 10.1111/xen.12390
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Journal ISSN0908-665X
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Creation24/10/2018 16:16:00
First validation24/10/2018 16:16:00
Update time09/01/2025 11:27:20
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