Scientific article
Open access

Impact of Tissue Classification in MRI-Guided Attenuation Correction on Whole-Body Patlak PET/MRI

Published inMolecular Imaging and Biology, vol. 21, no. 6, p. 1147-1156
Publication date2019

PURPOSE: The aim of this work is to investigate the impact of tissue classification in magnetic resonance imaging (MRI)-guided positron emission tomography (PET) attenuation correction (AC) for whole-body (WB) Patlak net uptake rate constant (Ki) imaging in PET/MRI studies. PROCEDURES: WB dynamic PET/CT data were acquired for 14 patients. The CT images were utilized to generate attenuation maps (μ-mapCTAC) of continuous attenuation coefficient values (Acoeff). The μ-mapCTAC were then segmented into four tissue classes (μ-map4-classes), namely background (air), lung, fat, and soft tissue, where a predefined Acoeff was assigned to each class. To assess the impact of bone for AC, the bones in the μ-mapCTAC were then assigned a predefined soft tissue Acoeff (0.1 cm-1) to produce an AC μ-map without bones (μ-mapno-bones). Thereafter, both WB static SUV and dynamic PET images were reconstructed using μ-mapCTAC, μ-map4-classes, and μ-mapno-bones (PETCTAC, PET4-classes, and PETno-bones), respectively. WB indirect and direct parametric Ki images were generated using Patlak graphical analysis. Malignant lesions were delineated on PET images with an automatic segmentation method that uses an active contour model (MASAC). Then, the quantitative metrics of the metabolically active tumor volume (MATV), target-to-background (TBR), contrast-to-noise ratio (CNR), peak region-of-interest (ROIpeak), maximum region-of-interest (ROImax), mean region-of-interest (ROImean), and metabolic volume product (MVP) were analyzed. The Wilcoxon test was conducted to assess the difference between PET4-classes and PETno-bones against PETCTAC for all images. The same test was also adopted to compare the differences between SUV, indirect Ki, and direct Ki images for each evaluated AC method. RESULTS: No significant differences in MATV, TBR, and CNR were observed between PET4-classes and PETCTAC for either SUV or Ki images. PET4-classes significantly overestimated ROIpeak, ROImax, ROImean, as well as MVP scores compared with PETCTAC in both SUV and Ki images. SUV images exhibited the highest median relative errors for PET4-classes with respect to PETCTAC (RE4-classes): 6.91 %, 6.55 %, 5.90 %, and 6.56 % for ROIpeak, ROImax, ROImean, and MVP, respectively. On the contrary, Ki images showed slightly reduced RE4-classes (indirect 5.52 %, 5.95 %, 4.43 %, and 5.70 %, direct 6.61 %, 6.33 %, 5.53 %, and 4.96 %) for ROIpeak, ROImax, ROImean, and MVP, respectively. A higher TBR was observed on indirect and direct Ki images relative to SUV, while direct Ki images demonstrated the highest CNR. CONCLUSIONS: Four-tissue class AC may impact SUV and Ki parameter estimation but only to a limited extent, thereby suggesting that WB Patlak Ki imaging for dynamic WB PET/MRI studies is feasible. Patlak Ki imaging can enhance TBR, thereby facilitating lesion segmentation and quantification. However, patient-specific Acoeff for each tissue class should be used when possible to address the high inter-patient variability of Acoeff distributions.

  • Whole-body PET/MRI
  • SUV
  • Patlak analysis
  • Tissue classification
  • Attenuation correction
NoteMerci de mettre à jour le pdf avec le fichier suivant:https://www.hug-ge.ch/sites/interhug/files/structures/pinlab/documents/mib2019_petmri.pdf
Citation (ISO format)
ZHUANG, Mingzan et al. Impact of Tissue Classification in MRI-Guided Attenuation Correction on Whole-Body Patlak PET/MRI. In: Molecular Imaging and Biology, 2019, vol. 21, n° 6, p. 1147–1156. doi: 10.1007/s11307-019-01338-1
Main files (1)
Article (Published version)
ISSN of the journal1536-1632

Technical informations

Creation03/08/2019 7:31:00 PM
First validation03/08/2019 7:31:00 PM
Update time03/15/2023 4:01:05 PM
Status update03/15/2023 4:01:04 PM
Last indexation05/03/2024 7:53:49 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack