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Local chromatin interactions contribute to expression of the fibrinogen gene cluster

ContributorsEspitia Jaimes, Cindy; Fish, Richardorcid; Neerman Arbez, Margueriteorcid
Published inJournal of Thrombosis and Haemostasis, vol. 16, no. 10, p. 2070-2082
Publication date2018
Abstract

Essentials: The fibrinogen gene cluster is flanked by CCCTC-binding factor (CTCF) interaction sites. Chromatin looping of the fibrinogen cluster was demonstrated by chromosome conformation capture. Deleting a CTCF interaction site alters chromatin looping and halves fibrinogen expression. Looping of the human fibrinogen locus is functionally linked to fibrinogen gene expression.

Keywords
  • CCCTC-binding factor
  • CRISPR-cas systems
  • Fibrinogen
  • Gene expression regulation
  • Multigene family
Affiliation entities
Research groups
Funding
  • Swiss National Science Foundation - #31003A_152633
Citation (ISO format)
ESPITIA JAIMES, Cindy, FISH, Richard, NEERMAN ARBEZ, Marguerite. Local chromatin interactions contribute to expression of the fibrinogen gene cluster. In: Journal of Thrombosis and Haemostasis, 2018, vol. 16, n° 10, p. 2070–2082. doi: 10.1111/jth.14248
Main files (2)
Article (Accepted version)
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Article (Published version)
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Identifiers
Journal ISSN1538-7836
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195downloads

Technical informations

Creation05/12/2018 15:25:00
First validation05/12/2018 15:25:00
Update15/03/2023 16:00:06
Status update15/03/2023 16:00:06
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