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Scientific article
English

Junctional adhesion molecule C (JAM-C) distinguishes CD27+ germinal center B lymphocytes from non-germinal center cells and constitutes a new diagnostic tool for B-cell malignancies

Published inLeukemia, vol. 21, no. 6, p. 1285-1293
Publication date2007
Abstract

Differentiation of naive B cells into plasma cells or memory cells occurs in the germinal centers (GCs) of lymph follicles or alternatively via a GC- and T-cell-independent pathway. It is currently assumed that B-cell lymphomas correlate to normal B-cell differentiation stages, but the precise correlation of several B-cell lymphomas to these two pathways remains controversial. In the present report, we describe the junctional adhesion molecule C (JAM-C), currently identified at the cell-cell border of endothelial cells, as a new B-cell marker with a tightly regulated expression during B-cell differentiation. Expression of JAM-C in tonsils allows distinction between two CD27+ B-cell subpopulations: JAM-C- GC B cells and JAM-C+ non-germinal B cells. The expression of JAM-C in different B-cell lymphomas reveals a disease-specific pattern and allows a clear distinction between JAM-C- lymphoproliferative syndromes (chronic lymphocytic leukemia, mantle cell lymphoma and follicular lymphoma) and JAM-C+ ones (hairy cell leukemia, marginal zone B-cell lymphoma). Therefore, we propose JAM-C as a new identification tool in B-cell lymphoma diagnosis.

Keywords
  • Antigens
  • CD27
  • B-Lymphocytes/ cytology
  • Cell Adhesion Molecules/ analysis
  • Germinal Center/ cytology
  • Humans
  • Leukemia
  • B-Cell/ diagnosis/pathology
  • Lymphoma
  • Tumor Markers
  • Biological
Citation (ISO format)
ODY, Christiane et al. Junctional adhesion molecule C (JAM-C) distinguishes CD27+ germinal center B lymphocytes from non-germinal center cells and constitutes a new diagnostic tool for B-cell malignancies. In: Leukemia, 2007, vol. 21, n° 6, p. 1285–1293. doi: 10.1038/sj.leu.2404689
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ISSN of the journal0887-6924
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