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Title

Interferon-beta induces brain-derived neurotrophic factor in peripheral blood mononuclear cells of multiple sclerosis patients
Authors
Lalive d'Epinay, Patrice
Kantengwa, S.
Benkhoucha, Mahdia
Juillard, C.
Chofflon, Michel
Published in Journal of Neuroimmunology. 2008, vol. 197, no. 2, p. 147-51
Abstract Interferon-beta (IFN-beta) achieves its beneficial effect on multiple sclerosis (MS) via anti-inflammatory properties. In this study, we assessed the expression of the brain-derived neurotrophic factor (BDNF) in peripheral blood mononuclear cells (PBMC) from relapsing-remitting multiple sclerosis (RRMS) patients treated or not with IFN-beta. Intracellular BDNF was measured by Western blot and ELISA and compared with serum BDNF. We found higher levels of BDNF in PBMC of IFN-beta-treated versus non-treated patients, whereas serum levels of BDNF were similar. We hypothesize that the increased intracellular BDNF secondary to IFN-beta is not released in the periphery. This release is probably not tissue specific but in MS patients, BDNF could be specifically delivered by PBMC at the site of re-activation, i.e. within the central nervous system.
Keywords Adult — Blotting, Western/methods — Brain-Derived Neurotrophic Factor/metabolism — Case-Control Studies — Dose-Response Relationship, Drug — Enzyme-Linked Immunosorbent Assay/methods — Female — Gene Expression Regulation/drug effects — Humans — Immunologic Factors/pharmacology — Interferon-beta/pharmacology — Leukocytes, Mononuclear/drug effects — Male — Middle Aged — Multiple Sclerosis/pathology
Identifiers
PMID: 18555540
Full text
Article (Accepted version) (257 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.sciencedirect.com/science/article/pii/S0165572808001306
Structures
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques
Research group Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843)
Citation
(ISO format) 		LALIVE D'EPINAY, Patrice et al. Interferon-beta induces brain-derived neurotrophic factor in peripheral blood mononuclear cells of multiple sclerosis patients. In: Journal of Neuroimmunology, 2008, vol. 197, n° 2, p. 147-51. doi: 10.1016/j.jneuroim.2008.04.033 https://archive-ouverte.unige.ch/unige:1142

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Deposited on : 2009-03-13

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