

Other version: http://www.sciencedirect.com/science/article/pii/S0165572808001306
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Interferon-beta induces brain-derived neurotrophic factor in peripheral blood mononuclear cells of multiple sclerosis patients |
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Published in | Journal of neuroimmunology. 2008, vol. 197, no. 2, p. 147-51 | |
Abstract | Interferon-beta (IFN-beta) achieves its beneficial effect on multiple sclerosis (MS) via anti-inflammatory properties. In this study, we assessed the expression of the brain-derived neurotrophic factor (BDNF) in peripheral blood mononuclear cells (PBMC) from relapsing-remitting multiple sclerosis (RRMS) patients treated or not with IFN-beta. Intracellular BDNF was measured by Western blot and ELISA and compared with serum BDNF. We found higher levels of BDNF in PBMC of IFN-beta-treated versus non-treated patients, whereas serum levels of BDNF were similar. We hypothesize that the increased intracellular BDNF secondary to IFN-beta is not released in the periphery. This release is probably not tissue specific but in MS patients, BDNF could be specifically delivered by PBMC at the site of re-activation, i.e. within the central nervous system. | |
Keywords | Adult — Blotting, Western/methods — Brain-Derived Neurotrophic Factor/metabolism — Case-Control Studies — Dose-Response Relationship, Drug — Enzyme-Linked Immunosorbent Assay/methods — Female — Gene Expression Regulation/drug effects — Humans — Immunologic Factors/pharmacology — Interferon-beta/pharmacology — Leukocytes, Mononuclear/drug effects — Male — Middle Aged — Multiple Sclerosis/pathology | |
Identifiers | PMID: 18555540 | |
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![]() ![]() Other version: http://www.sciencedirect.com/science/article/pii/S0165572808001306 |
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Research group | Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843) | |
Citation (ISO format) | LALIVE D'EPINAY, Patrice et al. Interferon-beta induces brain-derived neurotrophic factor in peripheral blood mononuclear cells of multiple sclerosis patients. In: Journal of neuroimmunology, 2008, vol. 197, n° 2, p. 147-51. doi: 10.1016/j.jneuroim.2008.04.033 https://archive-ouverte.unige.ch/unige:1142 |