Scientific article

Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth

Published inCancer research, vol. 65, no. 13, p. 5703-5710
Publication date2005

The junctional adhesion molecule-C (JAM-C) was recently described as an adhesion molecule localized at interendothelial contacts and involved in leukocyte transendothelial migration. The protein JAM-C interacts with polarity complex molecules and regulates the activity of the small GTPase Cdc42. The angiogenesis process involves rearrangement of endothelial junctions and implicates modulation of cell polarity. We tested whether JAM-C plays a role in angiogenesis using tumor grafts and hypoxia-induced retinal neovascularization. Treatment with a monoclonal antibody directed against JAM-C reduces tumor growth and infiltration of macrophages into tumors. The antibody decreases angiogenesis in the model of hypoxia-induced retinal neovascularization in vivo and vessel outgrowth from aortic rings in vitro. Importantly, the antibody does not induce pathologic side effects in vivo. These findings show for the first time a role for JAM-C in angiogenesis and define JAM-C as a valuable target for antitumor therapies.

  • Angiogenesis Inhibitors/ pharmacology/toxicity
  • Animals
  • Antibodies, Monoclonal/immunology/ pharmacology/toxicity
  • Apoptosis/drug effects
  • Carcinoma, Lewis Lung/ blood supply/pathology/ therapy
  • Cell Adhesion Molecules/ antagonists &
  • inhibitors/biosynthesis/immunology/metabolism
  • Cell Growth Processes/drug effects
  • Endothelial Cells/cytology/drug effects/metabolism
  • Female
  • Humans
  • Immunoglobulins/biosynthesis/immunology/metabolism
  • Membrane Proteins/ antagonists & inhibitors/biosynthesis/immunology/metabolism
  • Mice
  • Mice, Inbred C57BL
  • Neovascularization, Pathologic/drug therapy/immunology/pathology
  • Neovascularization, Physiologic/drug effects/immunology
  • Retinal Vessels/cytology
  • Vascular Endothelial Growth Factor A/metabolism
Affiliation Not a UNIGE publication
Citation (ISO format)
LAMAGNA, Chrystelle et al. Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth. In: Cancer research, 2005, vol. 65, n° 13, p. 5703–5710. doi: 10.1158/0008-5472.CAN-04-4012
Updates (1)
ISSN of the journal0008-5472

Technical informations

Creation08/27/2010 1:35:16 PM
First validation08/27/2010 1:35:16 PM
Update time03/14/2023 4:04:07 PM
Status update03/14/2023 4:04:07 PM
Last indexation08/28/2023 7:36:32 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack