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Title

Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary study

Authors
Pievani, Michela
Bocchetta, Martina
Cavedo, Enrica
Bonetti, Matteo
Thompson, Paul M
Published in Neurobiology of Aging. 2013, vol. 34, no. 7, p. 1728-1739
Abstract We investigated volume and shape changes in the striatum (caudate, putamen, and nucleus accumbens) of 18 early-onset (EOAD) and 18 late-onset (LOAD) Alzheimer's Disease patients compared with 2 control groups age- and sex-matched to each patient group, and explored the relationship between striatal atrophy and apolipoprotein E (APOE) genotype. EOAD patients showed significant shape changes in the left and right ventral putamen (p < 0.05, corrected for multiple comparison with permutation tests). LOAD patients showed significant reductions in the left and right nucleus accumbens volumes (p < 0.05; Mann-Whitney test) and shape (p < 0.05; permutation test). Caudate abnormalities were detected in EOAD and LOAD patients in terms of local enlargements and reductions (p < 0.05 for the left and right, permutation test). When APOE was considered, significant differences were detected between LOAD ε4 carriers and noncarriers in the left and right caudate (p < 0.05, permutation test). These results suggest distinct patterns of striatal pathology in EOAD and LOAD patients, the dorsal striatum being involved in EOAD and the ventral striatum in LOAD.
Keywords Age FactorsAge of OnsetAgedAged, 80 and overAlzheimer Disease/epidemiology/genetics/pathologyApolipoproteins E/geneticsCorpus Striatum/pathologyFemaleHumansMagnetic Resonance Imaging/methodsMaleMiddle Aged
Identifiers
PMID: 23428181
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PIEVANI, Michela et al. Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary study. In: Neurobiology of Aging, 2013, vol. 34, n° 7, p. 1728-1739. doi: 10.1016/j.neurobiolaging.2013.01.016 https://archive-ouverte.unige.ch/unige:114058

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Deposited on : 2019-02-08

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