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Scientific article
English

Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary study

Published inNeurobiology of Aging, vol. 34, no. 7, p. 1728-1739
Publication date2013
Abstract

We investigated volume and shape changes in the striatum (caudate, putamen, and nucleus accumbens) of 18 early-onset (EOAD) and 18 late-onset (LOAD) Alzheimer's Disease patients compared with 2 control groups age- and sex-matched to each patient group, and explored the relationship between striatal atrophy and apolipoprotein E (APOE) genotype. EOAD patients showed significant shape changes in the left and right ventral putamen (p < 0.05, corrected for multiple comparison with permutation tests). LOAD patients showed significant reductions in the left and right nucleus accumbens volumes (p < 0.05; Mann-Whitney test) and shape (p < 0.05; permutation test). Caudate abnormalities were detected in EOAD and LOAD patients in terms of local enlargements and reductions (p < 0.05 for the left and right, permutation test). When APOE was considered, significant differences were detected between LOAD ε4 carriers and noncarriers in the left and right caudate (p < 0.05, permutation test). These results suggest distinct patterns of striatal pathology in EOAD and LOAD patients, the dorsal striatum being involved in EOAD and the ventral striatum in LOAD.

Keywords
  • Age Factors
  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease/epidemiology/genetics/pathology
  • Apolipoproteins E/genetics
  • Corpus Striatum/pathology
  • Female
  • Humans
  • Magnetic Resonance Imaging/methods
  • Male
  • Middle Aged
Affiliation Not a UNIGE publication
Citation (ISO format)
PIEVANI, Michela et al. Striatal morphology in early-onset and late-onset Alzheimer’s disease: a preliminary study. In: Neurobiology of Aging, 2013, vol. 34, n° 7, p. 1728–1739. doi: 10.1016/j.neurobiolaging.2013.01.016
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0197-4580
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