For patients with full thickness skin defects such as second and third degree burns, autologous skin grafts and autologous cultured epidermis are considered as the gold standard treatments (For details see Appendix 1-3). However, skin grafts can have undesirable outcomes resulting from scars, poor elasticity, and limitations in joint movement due to contractures. Many times, grafted tissue does not have the same properties as the original tissue in terms of elasticity and the scarring process can make the tissue more rigid, which is a problem for delicate regions, like the neck. The rigidity of grafted tissue can make movement and mobility difficult and it is under these circumstances, that extracellular matrix (ECM) scaffolds are usefull. In these cases skin substitutes such as extracellular matrix scaffolds can be used to improve functional outcome of delicate zones. Actually decellularized dermis seems to be the best acellular skin substitute, with no other scaffold being clinically proven to gain better results yet.