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Title

ChT1, an Ig superfamily molecule required for T cell differentiation

Authors
Katevuo, K.
Boyd, R.
Chidgey, A.
Bean, A.
Dunon, D.
Gobel, T. W.
Vainio, O.
Published in The Journal of immunology. 1999, vol. 162, no. 10, p. 5685-5694
Abstract The thymus is colonized by circulating progenitor cells that differentiate into mature T cells under the influence of the thymic microenvironment. We report here the cloning and function of the avian thymocyte Ag ChT1, a member of the Ig superfamily with one V-like and one C2-like domain. ChT1-positive embryonic bone marrow cells coexpressing c-kit give rise to mature T cells upon intrathymic cell transfer. ChT1-specific Ab inhibits T cell differentiation in embryonic thymic organ cultures and in thymocyte precursor cocultures on stromal cells. Thus, we provide clear evidence that ChT1 is a novel Ag on early T cell progenitors that plays an important role in the early stages of T cell development.
Keywords Amino Acid SequenceAnimalsAntigens, CD5/genetics/ immunologyAntigens, Surface/geneticsBase SequenceBone Marrow TransplantationCell DifferentiationChick EmbryoChickensCloning, MolecularDNA, Complementary/geneticsHematopoietic Stem Cells/immunologyImmunoglobulins/genetics/ immunologyLymphoid Tissue/embryology/immunologyMembrane Proteins/geneticsMolecular Sequence DataOrgan Culture TechniquesProto-Oncogene Proteins c-kit/isolation & purificationSequence Analysis, DNASequence Homology, Amino AcidT-Lymphocytes/ cytology/ immunologyThymus Gland/cytology/ immunology/surgeryTissue Distribution
Identifiers
PMID: 10229800
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Other version: http://www.jimmunol.org/cgi/reprint/162/10/5685.pdf
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KATEVUO, K. et al. ChT1, an Ig superfamily molecule required for T cell differentiation. In: The Journal of immunology, 1999, vol. 162, n° 10, p. 5685-5694. https://archive-ouverte.unige.ch/unige:11370

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Deposited on : 2010-08-27

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