The occurrence of antibodies against single-stranded DNA in the sera of patients with acute and chronic leukaemia

Izui, Shozo; Lambert, Paul Henri; Carpentier, N.; Miescher, P. A.

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Title		The occurrence of antibodies against single-stranded DNA in the sera of patients with acute and chronic leukaemia
Authors		Izui, Shozo Lambert, Paul Henri Carpentier, N. Miescher, P. A.
Published in		Clinical and experimental immunology. 1976, vol. 24, no. 3, p. 379-384
Abstract		One hundred and seventy-five sera from thirty-three patients with acute myeloid leukaemia, forty-two patients with chronic myeloid leukaemia and twelve patients with acute lymphatic leukaemia were examined by a radioimmunological technique for the presence of antibodies against single-stranded and double-stranded DNA. The levels of single-stranded DNA binding activity was significantly higher in all three types of leukaemia compared to those of healthy controls. In contrast, none of these sera exhibited a positive reaction with double-stranded DNA. In some cases the level of serum anti-DNA antibodies increased after the decrease of the leucocyte count. The presence of anti-DNA antibodies in leukaemic patients may have some biological significance.
Keywords		Antibodies, Neoplasm/analysis — BCG Vaccine — DNA, Single-Stranded/ immunology — Female — Follow-Up Studies — Humans — Hydroxyurea/therapeutic use — Immunotherapy — Leukemia, Lymphoid/ immunology — Leukemia, Myeloid/ immunology/therapy — Leukemia, Myeloid, Acute/ immunology — Leukocyte Count — Male — Mycobacterium bovis/immunology
Identifiers		PMID: 780020
Full text		Article - Limited access to UNIGE Other version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538528/pdf/clinexpimmunol00250-0003.pdf
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Citation (ISO format)		IZUI, Shozo et al. The occurrence of antibodies against single-stranded DNA in the sera of patients with acute and chronic leukaemia. In: Clinical and experimental immunology, 1976, vol. 24, n° 3, p. 379-384. https://archive-ouverte.unige.ch/unige:11340