

Other version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538528/pdf/clinexpimmunol00250-0003.pdf
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The occurrence of antibodies against single-stranded DNA in the sera of patients with acute and chronic leukaemia |
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Published in | Clinical and experimental immunology. 1976, vol. 24, no. 3, p. 379-384 | |
Abstract | One hundred and seventy-five sera from thirty-three patients with acute myeloid leukaemia, forty-two patients with chronic myeloid leukaemia and twelve patients with acute lymphatic leukaemia were examined by a radioimmunological technique for the presence of antibodies against single-stranded and double-stranded DNA. The levels of single-stranded DNA binding activity was significantly higher in all three types of leukaemia compared to those of healthy controls. In contrast, none of these sera exhibited a positive reaction with double-stranded DNA. In some cases the level of serum anti-DNA antibodies increased after the decrease of the leucocyte count. The presence of anti-DNA antibodies in leukaemic patients may have some biological significance. | |
Keywords | Antibodies, Neoplasm/analysis — BCG Vaccine — DNA, Single-Stranded/ immunology — Female — Follow-Up Studies — Humans — Hydroxyurea/therapeutic use — Immunotherapy — Leukemia, Lymphoid/ immunology — Leukemia, Myeloid/ immunology/therapy — Leukemia, Myeloid, Acute/ immunology — Leukocyte Count — Male — Mycobacterium bovis/immunology | |
Identifiers | PMID: 780020 | |
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![]() ![]() Other version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538528/pdf/clinexpimmunol00250-0003.pdf |
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Citation (ISO format) | IZUI, Shozo et al. The occurrence of antibodies against single-stranded DNA in the sera of patients with acute and chronic leukaemia. In: Clinical and experimental immunology, 1976, vol. 24, n° 3, p. 379-384. https://archive-ouverte.unige.ch/unige:11340 |