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Control of central self-tolerance induction by autoreactive CD4+ thymocytes

Hollander, Georg
Published in Trends in Immunology. 2010, vol. 31, no. 2, p. 71-79
Abstract Medullary thymic epithelial cells (mTECs) are crucial for the selection of a T-cell-receptor (TCR) repertoire purged of self-reactive specificities, because these cells activate a promiscuous gene-expression program that leads to the synthesis of a wide array of peripheral tissue-restricted self-antigens. This review summarizes recent progress in our understanding of the cellular interactions, ligands, receptors and signal-transduction pathways that control mature-mTEC development. The particular focus is on new findings supporting the model that mature-mTEC development in the postnatal thymus depends on nuclear factor-kappaB (NF-kappaB) signaling induced by CD40-CD40 ligand, and receptor-activator-of-NF-kappaB (RANK)-RANK ligand interactions, and that these signals are delivered in the context of antigen-specific interactions between CD4(+) thymocytes carrying autoreactive TCRs and mTECs displaying cognate autoantigen-MHC-class-II complexes.
Keywords AnimalsAntigens, CD4/immunologyAutoimmunityEpithelial Cells/cytology/immunology/metabolismHumansReceptors, Antigen, T-Cell/immunologySelf ToleranceSignal TransductionThymus Gland/cytology/ immunology/metabolism
PMID: 20004147
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Research group Groupe Reith Walter (pathologie et immunologie) (282)
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IRLA, Magali, HOLLANDER, Georg, REITH, Walter. Control of central self-tolerance induction by autoreactive CD4+ thymocytes. In: Trends in Immunology, 2010, vol. 31, n° 2, p. 71-79. https://archive-ouverte.unige.ch/unige:11334

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Deposited on : 2010-08-27

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