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Scientific article
English

Pulmonary dysfunction and impaired granulocyte homeostasis result in poor survival of Jam-C-deficient mice

Published inJournal of pathology, vol. 212, no. 2, p. 198-208
Publication date2007
Abstract

Jam-C(-/-) mice exhibit growth retardation and multilobular pneumonia concomitant with poor survival of the mice under conventional housing conditions. The deficient mice present a mega-oesophagus and have altered airway responsiveness. In addition, the number of circulating granulocytes is increased in Jam-C(-/-) mice as compared to control animals. These phenotypes probably reflect the different functions of JAM-C expressed by endothelial and mesenchymal cells. Indeed, the deregulation in the number of circulating granulocytes is caused by the lack of JAM-C expression on endothelial cells since rescuing endothelial expression of the protein in the Jam-C(-/-) mice is sufficient to restore homeostasis. More importantly, the rescue of vascular JAM-C expression is accompanied by better survival of deficient mice, suggesting that endothelial expression of JAM-C is mandatory for animal survival from opportunistic infections and fatal pneumonia.

Keywords
  • Animals
  • Bronchi/immunology
  • Cell Adhesion Molecules/analysis/ deficiency/immunology
  • Disease Susceptibility/immunology
  • Endothelial Cells/immunology
  • Esophageal Achalasia/immunology/physiopathology
  • Esophagus/immunology/physiopathology
  • Granulocytes/ immunology
  • Homeostasis/ immunology
  • Immunoglobulins/analysis/ deficiency/immunology
  • Immunohistochemistry/methods
  • Leukocyte Count
  • Lung/ immunology/physiopathology
  • Membrane Proteins/analysis/ deficiency/immunology
  • Mice
  • Mice, Mutant Strains
  • Muscle, Smooth/immunology
  • Neutrophils/immunology
  • Peritonitis/immunology/physiopathology
  • Pneumonia/immunology
  • Receptors, CXCR4/analysis
Affiliation Not a UNIGE publication
Citation (ISO format)
IMHOF, Beat et al. Pulmonary dysfunction and impaired granulocyte homeostasis result in poor survival of Jam-C-deficient mice. In: Journal of pathology, 2007, vol. 212, n° 2, p. 198–208. doi: 10.1002/path.2163
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ISSN of the journal0022-3417
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