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Title

Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C

Authors
Gliki, Georgia
Ebnet, Klaus
Adams, R. H.
Published in Nature. 2004, vol. 431, no. 7006, p. 320-324
Abstract During spermatogenesis in the mammalian testis, stem cells (spermatogonia) differentiate into spermatocytes, which subsequently undergo two consecutive meiotic divisions to give rise to haploid spermatids. These cells are initially round but progressively elongate, condense their nuclei, acquire flagellar and acrosomal structures, and shed a significant amount of their cytoplasm to form spermatozoa (the sperm cells) in a developmental cascade termed spermiogenesis. Defects in these processes will lead to a lack of mature sperm cells (azoospermia), which is a major cause of male infertility in the human population. Here we report that a cell-surface protein of the immunoglobulin superfamily, junctional adhesion molecule-C (JAM-C), is critically required for the differentiation of round spermatids into spermatozoa in mice. We found that Jam-C is essential for the polarization of round spermatids, a function that we attribute to its role in the assembly of a cell polarity complex.
Keywords AnimalsCell Adhesion Molecules/deficiency/genetics/ metabolismCell DifferentiationCell PolarityGene DeletionMaleMiceMice, KnockoutSpermatids/ cytology/ metabolismSpermatogenesiscdc42 GTP-Binding Protein/metabolism
Identifiers
PMID: 15372036
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GLIKI, Georgia et al. Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C. In: Nature, 2004, vol. 431, n° 7006, p. 320-324. https://archive-ouverte.unige.ch/unige:11275

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Deposited on : 2010-08-27

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